单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Ophthalmol,Wuhan 430030,Peoples R China眼科华中科技大学同济医学院附属同济医院[2]Wuhan Univ, Zhongnan Hosp, Reprod Med Ctr, Wuhan 430071, Peoples R China[3]Texas A&M Univ, Off Texas State Chemist, College Stn, TX 77845 USA
Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced oxidation of polyunsaturated fatty acids (PUFAs), are extraordinarily reactive, forming covalent adducts incorporating protein lysyl epsilon-amino groups. Because they accumulate, these adducts provide a dosimeter of oxidative injury. This review provides an updated and comprehensive overview of the generation of LG/isoLG in vitro and in vivo and the detection methods for the adducts of LG/isoLG and biological molecules in vivo.
第一作者单位：[2]Wuhan Univ, Zhongnan Hosp, Reprod Med Ctr, Wuhan 430071, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Ming,Li Wei,Li Tao.Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo[J].MOLECULES.2011,16(7):5333-5348.doi:10.3390/molecules16075333.
APA：
Zhang, Ming,Li, Wei&Li, Tao.(2011).Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo.MOLECULES,16,(7)
MLA：
Zhang, Ming,et al."Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo".MOLECULES 16..7(2011):5333-5348
