国家重点研发计划(2018YFC1314700)%国家自然科学基金(81572234)%上海市教育委员会曙光计划(14SG21)%上海市市级医疗卫生优秀学科带头人培养计划(2017BR029)A China National Key R&D Program(no.2018YFC1314700)%National Natural Science Foundation of China(grant 81572234)%the Education Development Foundation of Shanghai's Municipal Education Commission(grant 14SG21)%Shanghai Municipal Medical and Health Excellent Academic Leaders Training Program(grant 2017BR029)