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A Case of NCAM1-Positive Lupus Nephritis with NCAM1 Antibody Titers Responsive to Rituximab

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单位： [1]Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, China [2] Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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关键词： Lupus nephritis Membranous nephropathy Neural cell adhesion molecule 1 Rituximab Case report

摘要：

Neural cell adhesion molecule 1 (NCAM1) is a recently identified new antigen of membranous nephropathy (MN) mostly secondary to systemic lupus erythematosus with a low positive rate of 6.6%, and its corresponding antibody was detected in patients' sera. Here, we reported a case of NCAM1-positive lupus nephritis (class V+III) developed from MN. The patient was refractory to multiple immunosuppressive regimens but achieved remission after the application of rituximab as an add-on therapy and showed a reduction of anti-NCAM1 antibody and proteinuria.© 2023 S. Karger AG, Basel.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区泌尿学与肾脏学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区泌尿学与肾脏学

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第一作者单位： [1]Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, China

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