单位：[1]National Center for Respiratory Diseases[2]State Key Laboratory of Respiratory Health and Multimorbidity[3]National Clinical Research Center for Respiratory Diseases[4]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences[5]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P. R. China.[6]School of Health Policy and Management, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China.[7]Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital Shanxi Academy of Medical Sciences, Taiyuan, Shanxi Province, P. R. China.[8]Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, P. R. China.内科学系呼吸内科华中科技大学同济医学院附属同济医院[9]Department of Pulmonary and Critical Care Medicine, Guizhou Provincial People’s Hospital, Guiyang, Guizhou Province, P. R. China.[10]Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.[11]Department of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning Province, P. R. China.[12]National Center for Respiratory Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, P. R. China.[13]Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang Province, P. R. China.[14]State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan Province, P. R. China.四川大学华西医院[15]Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Beijing, P. R. China.北京朝阳医院[16]Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, P. R. China.[17]Department of Respiratory and Critical Care Medicine, National Center of Gerontology， Beijing Hospital, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P. R. China.[18]Department of Epidemiology and Biostatistics, School of Basic Medicine of Peking Union Medical College, Institute of Basic Medical Sciences of Chinese Academy of Medical Sciences, Beijing, P. R. China.[19]National Center for Respiratory Diseases[20]State Key Laboratory of Respiratory Health and Multimorbidity[21]National Clinical Research Center for Respiratory Diseases[22]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences[23]Department of Clinical Research and Data Management, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P. R. China.[24]Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.
Spirometry reference equations that are derived from a large, nationally representative, general population are warranted in China and the impact of using pre- and post-BD spirometry reference values has yet to be assessed in Chinese populations.To present both the pre-BD and post-BD spirometry reference values for Chinese adults using the China Pulmonary Health (CPH) study.A reference population of 17969 healthy, non-smoking participants in the CPH study was used to calculate the pre- and post-BD reference values for the forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC. Both pre- and post-BD reference values were applied to the entire CPH population (50991 individuals) to illustrate the divergence between the use of references in determining the disease prevalence and severity grading.The prevalence of airflow limitation was 5.36% using pre-BD reference and 8.02% using the post-BD reference. Individuals who had post-BD FEV1/FVC below post-BD but higher than pre-BD reference values were found to have significantly higher rates of self-reported respiratory symptoms, and significantly lower values in spirometry indicators than those above post-BD reference values. An additional 3.51% of participants were identified as grade II-IV COPD using the post-BD FEV1 predicted values.This study generated and applied pre- and post-bronchodilator spirometry reference values in a nationally representative Chinese adult population. Post-BD reference values may serve as an additional criterion in identifying individuals at risk for obstructive pulmonary diseases, its diagnostic and prognostic values should be further investigated.
基金：
CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-I2M1-049) and Major Program of the National Nature Science Foundation of China (82090010).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|1 区医学
小类|1 区危重病医学1 区呼吸系统
最新[2025]版：
大类|1 区医学
小类|1 区危重病医学1 区呼吸系统
第一作者：
第一作者单位：[1]National Center for Respiratory Diseases[2]State Key Laboratory of Respiratory Health and Multimorbidity[3]National Clinical Research Center for Respiratory Diseases[4]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences[5]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P. R. China.
共同第一作者：
通讯作者：
通讯机构：[1]National Center for Respiratory Diseases[2]State Key Laboratory of Respiratory Health and Multimorbidity[3]National Clinical Research Center for Respiratory Diseases[4]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences[5]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P. R. China.[24]Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.
推荐引用方式(GB/T 7714)：
Huang Ke,Han Xueyan,Pan Zhaoyang,et al.Impact of Using Pre- and Post-Bronchodilator Spirometry Reference Values in a Chinese Population[J].American Journal Of Respiratory And Critical Care Medicine.2024,doi:10.1164/rccm.202308-1488OC.
APA：
Huang Ke,Han Xueyan,Pan Zhaoyang,Xu Jianying,Zhao Jianping...&Wang Chen.(2024).Impact of Using Pre- and Post-Bronchodilator Spirometry Reference Values in a Chinese Population.American Journal Of Respiratory And Critical Care Medicine,,
MLA：
Huang Ke,et al."Impact of Using Pre- and Post-Bronchodilator Spirometry Reference Values in a Chinese Population".American Journal Of Respiratory And Critical Care Medicine .(2024)
医学