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Increased expression of ficolin-1 is associated with airway obstruction in asthma

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收录情况： ◇ SCIE

作者：
Gao Pengfei[1,2] * ; Tang Kun[3,4] ; Lu Yanjiao[3] ; Wang Meijia[3] ; Wang Wei[5] ; Wang Tongsheng[5] ; Sun Yuxia[5] ; Zhao Jianping[6] ; Mao Yimin[7] ;
单位： [1]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China. [2]Department of Respiratory and Critical Care Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [3]Department of Respiratory and Critical Care Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [4]Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. [5]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China. [6]Department of Respiratory and Critical Care Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [7]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China.
出处：
DOI： 10.1186/s12890-023-02772-2
ISSN：

关键词： Asthma Ficolins Pulmonary function Asthma control questionnaire

摘要：
The activated complement cascade is involved in asthmatic airway inflammation. Ficolins are essential for innate immunity and can activate the complement lectin pathway. Despite this, the significance of ficolins in asthma has yet to be determined. This study aimed to explore the presence of ficolins in individuals with asthma and to determine the relationship between ficolins and clinical characteristics.For the study, 68 asthmatic patients and 30 healthy control subjects were recruited. Enzyme-linked immunosorbent assay was used to determine plasma ficolin-1, ficolin-2, and ficolin-3 concentrations both before and after inhaled corticosteroid (ICS) therapy. Further, the associations of plasma ficolin-1 level with pulmonary function and asthma control questionnaire (ACQ) score were examined in the asthma patients.Patients with asthma exhibited significantly elevated plasma ficolin-1 levels (median, 493.9 ng/mL; IQR, 330.2-717.8 ng/mL) in comparison to healthy controls (median, 330.6 ng/mL; IQR, 233.8-371.1 ng/mL). After ICS treatment, plasma ficolin-1 (median, 518.1 ng/mL; IQR, 330.2-727.0 ng/mL) in asthmatic patients was significantly reduced (median, 374.7 ng/mL; IQR, 254.8-562.5 ng/mL). Additionally, ficolin-1 expressions in plasma were significantly correlated with pulmonary function parameters and ACQ score in asthmatic patients. Asthma patients with higher plasma ficolin-1 levels demonstrated poorer lung function than those with lower plasma ficolin-1 levels.The results revealed that asthmatic patients had higher plasma ficolin-1 concentrations, which decreased after ICS treatment and were linked to their lung function, implying a potential involvement of ficolin-1 in asthma pathogenesis.© 2023. The Author(s).

基金：
This work was supported by the Science and Technology Development Program of Henan Province (No. 222102310533, 222103810052), the Natural Science Foundation of Henan Province (No. 232300421304), and the Young Elite Scientists Sponsorship Program by Luoyang Association for Science and Technology (No. 2022HLTJ18).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 4 区 呼吸系统
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 呼吸系统
JCR分区：
出版当年[2021]版：
Q3 RESPIRATORY SYSTEM
最新[2023]版：
Q2 RESPIRATORY SYSTEM

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China. [2]Department of Respiratory and Critical Care Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
通讯作者：
通讯机构： [1]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China. [2]Department of Respiratory and Critical Care Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
推荐引用方式(GB/T 7714)：
Gao Pengfei,Tang Kun,Lu Yanjiao,et al.Increased expression of ficolin-1 is associated with airway obstruction in asthma[J].BMC PULMONARY MEDICINE.2023,23(1):doi:10.1186/s12890-023-02772-2.
APA：
Gao Pengfei,Tang Kun,Lu Yanjiao,Wang Meijia,Wang Wei...&Mao Yimin.(2023).Increased expression of ficolin-1 is associated with airway obstruction in asthma.BMC PULMONARY MEDICINE,23,(1)
MLA：
Gao Pengfei,et al."Increased expression of ficolin-1 is associated with airway obstruction in asthma".BMC PULMONARY MEDICINE 23..1(2023)

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