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Prognostic evaluation of lymph-vascular space invasion in patients with endometrioid and non-endometrioid endometrial cancer: A multicenter study

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作者：
Feng Jie[1,2] * ; Zhang Yue[1,2] * ; Huang Changzhen[1,2] * ; Li Li[1] * ; Liu Jihong[3] * ; Wang Jianliu[4] * ; Guo Hongyan[5] * ; Yao Shuzhong[6] * ; Cui Zhumei[7] ; Chen Gang[8] ; Gao Qinglei[8] ; Sun Chaoyang[8] ; Ma Ding[8] ; Wang Beibei[8,*2] ; Li Yang[9,*2] ; Chu Ran[1,2,*1] ; Kong Beihua[1,2,*1] ;
单位： [1]Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China [2]Division of Gynecology Oncology, Qilu Hospital of Shandong University, Jinan, 250012, China [3]Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China [4]Peking University People’s Hospital, Beijing, 100044, China [5]The Third Hospital of Peking University, Beijing, 100191, China [6]Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat- Sen University, Guangzhou, 510080, China [7]Department of Gynecology and Obstetrics, The Affiliated Yantai Yuhuangding Hospital of Qindao University, Yantai, 264000, China [8]Department of Gynecology and Obstetrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,430000,China [9]Women’s Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China
出处：
DOI： 10.1016/j.ejso.2024.108261
ISSN：

关键词： Endometrial cancer Lymph-vascular space invasion Endometrioid endometrial cancer Non-endometrioid endometrial cancer Prognosis

摘要：
The prognostic value of lymph-vascular space invasion (LVSI) on endometrial cancer (EC) remains controversial. This study aimed to explore the impact of LVSI on patients with endometrioid and non-endometrioid EC in China.We analyzed EC patients who underwent surgery from 2010 to 2019 in seven Chinese hospitals retrospectively and stratified patients based on histopathologic types and LVSI status. Endpoints were disease-free survival (DFS) and overall survival (OS). Propensity score matching (PSM) algorithm was used to balance the confounding factors. The survival was examined using Kaplan-Meier analysis. Cox proportional hazards regression analyses were used to find prognostic independent risk factors.Among 3715 EC patients, LVSI positive rate was 9.31% (346/3715). After matching, LVSI present group had shorter DFS (P = 0.005), and similar OS (P = 0.656) than LVSI absent group for endometrioid EC patients. For non-endometrioid EC patients, there was no statistical difference in either DFS (P = 0.536) or OS (P = 0.512) after matching. The multivariate Cox analysis showed that LVSI was an independent risk factor of DFS [hazard ratio (HR) 2.62, 95% confidence intervals (CI) 1.35-5.10, P = 0.005] and not OS (HR 1.24, 95%CI 0.49-3.13, P = 0.656) for endometrioid EC patients. It was not a prognostic factor of either DFS (HR 1.28, 95%CI 0.58-2.81, P = 0.539) or OS (HR 1.33, 95%CI 0.55-3.13, P = 0.515) for non-endometrioid EC patients.LVSI is an adverse prognostic factor for endometrioid EC patients and has no impact on non-endometrioid EC patients. Necessity of postoperative adjuvant therapy based on LVSI needs to be carefully considered for non-endometrioid EC patients.© 2024 Published by Elsevier Ltd.

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中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学 2 区 外科
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学 2 区 外科
JCR分区：
出版当年[2022]版：
Q1 SURGERY Q2 ONCOLOGY
最新[2023]版：
Q1 SURGERY Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者单位： [1]Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China [2]Division of Gynecology Oncology, Qilu Hospital of Shandong University, Jinan, 250012, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China [2]Division of Gynecology Oncology, Qilu Hospital of Shandong University, Jinan, 250012, China [8]Department of Gynecology and Obstetrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,430000,China [9]Women’s Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China [*1]Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong, 250012, China [*2]Department of Gynecology and Obstetrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,430000,China [*3]Department of Gynecologic Oncology, Women’s Hospital, Zhejiang University, School of Medicine, Xueshi Road 1, Hangzhou, Zhejiang, 310006, China
推荐引用方式(GB/T 7714)：
Feng Jie,Zhang Yue,Huang Changzhen,et al.Prognostic evaluation of lymph-vascular space invasion in patients with endometrioid and non-endometrioid endometrial cancer: A multicenter study[J].European Journal Of Surgical Oncology : The Journal Of The European Society Of Surgical Oncology And The British Association Of Surgical Oncology.2024,50(4):108261.doi:10.1016/j.ejso.2024.108261.
APA：
Feng Jie,Zhang Yue,Huang Changzhen,Li Li,Liu Jihong...&Kong Beihua.(2024).Prognostic evaluation of lymph-vascular space invasion in patients with endometrioid and non-endometrioid endometrial cancer: A multicenter study.European Journal Of Surgical Oncology : The Journal Of The European Society Of Surgical Oncology And The British Association Of Surgical Oncology,50,(4)
MLA：
Feng Jie,et al."Prognostic evaluation of lymph-vascular space invasion in patients with endometrioid and non-endometrioid endometrial cancer: A multicenter study".European Journal Of Surgical Oncology : The Journal Of The European Society Of Surgical Oncology And The British Association Of Surgical Oncology 50..4(2024):108261

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