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MAVS Ubiquitylation: Function, Mechanism, and Beyond

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收录情况： ◇ SCIE

作者：

单位： [1]Department of GI Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,Hubei,China. [2]GI Cancer Research Institute,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,Hubei,China.

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关键词： MAVS; ubiquitylation; SUMOylation; RING-finger type E3 ligase; HECT E3 ligase; U-box type E3 ligase; SUMO E3 ligase; virus-derived proteins function as E3 ligase; de-ubiquitinase

摘要：

The mitochondrial antiviral-signaling protein (MAVS), a core adaptor protein in the retinoic-acid-inducible gene-I-like receptors (RLRs)-MAVS pathway, has been demonstrated to play an important role in antiviral immune response and tumor immunology. Previous studies revealed that ubiquitylation is a key mechanism in the regulation of the RLRs-MAVS axis and immune response. Multiple E3 ubiquitin ligases and deubiquitinating enzymes control MAVS ubiquitylation and changes in MAVS function. In this review, we summarize the biological function of ubiquitylation in MAVS-related signaling and provide new insight into immunotherapy approaches that target MAVS.© 2024 The Author(s). Published by IMR Press.

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出版当年[2023]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

JCR分区：

出版当年[2022]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3.3 最新[2023版] 3.6 最新五年平均 3.1 出版当年[2022版] 3.9 出版当年五年平均 3.115 出版前一年[2021版] 3.3 出版后一年[2023版]

第一作者：

第一作者单位： [1]Department of GI Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,Hubei,China. [2]GI Cancer Research Institute,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,Hubei,China.

通讯作者：

通讯机构： [1]Department of GI Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,Hubei,China. [2]GI Cancer Research Institute,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,Hubei,China.

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MAVS Ubiquitylation: Function, Mechanism, and Beyond

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