The spotlight in recent years has increasingly focused on inducible regulatory T cells 35 (iTr35), a novel subpopulation of regulatory T cells characterized by phenotypic stability, heightened reactivity, and potent immunosuppressive function through the production of IL-35. Despite being in the exploratory phase, research on iTr35 has garnered significant interest. In this review, we aim to consolidate our understanding of the biological characteristics and immunomodulatory mechanisms of iTr35, offering fresh perspectives that may pave the way for its potential applications in disease diagnosis and treatment.
基金：
This work was supported by grants from the National Key
Research and Development Program of China (No.2022YFA1105303)
and the National Natural Science Foundation of China (82270903 and
81974254).
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Rheumatol & Immunol,Wuhan 430030,Hubei,Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Rheumatol & Immunol,Wuhan 430030,Hubei,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Hosp,Inst Allergy & Clin Immunol,Tongji Med Coll,Wuhan 430030,Hubei,Peoples R China
推荐引用方式(GB/T 7714)：
Yang Chenxi,Dong Lingli,Zhong Jixin.Immunomodulatory effects of iTr35 cell subpopulation and its research progress[J].CLINICAL AND EXPERIMENTAL MEDICINE.2024,24(1):doi:10.1007/s10238-024-01303-5.
APA：
Yang, Chenxi,Dong, Lingli&Zhong, Jixin.(2024).Immunomodulatory effects of iTr35 cell subpopulation and its research progress.CLINICAL AND EXPERIMENTAL MEDICINE,24,(1)
MLA：
Yang, Chenxi,et al."Immunomodulatory effects of iTr35 cell subpopulation and its research progress".CLINICAL AND EXPERIMENTAL MEDICINE 24..1(2024)
