Proton-activated G protein-coupled receptors (GPCRs), initially discovered by Ludwig in 2003, are widely distributed in various tissues. These receptors have been found to modulate the immune system in several inflammatory diseases, including inflammatory bowel disease, atopic dermatitis, and asthma. Proton-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular pH. This detection triggers downstream signaling pathways within the cells, ultimately influencing the function of immune cells. In this review, we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.
基金：
This study was supported by the National Nature Science Foundation of China (No. 81873694), the Key Research and Development Program of Hubei Province (No. 2022BCA005), and Knowledge Innovation Program of Wuhan Basic Research (No. 2022020801010446).
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Otolaryngol Head & Neck Surg,Wuhan 430030,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Hosp,Inst Allergy & Clin Immunol,Tongji Med Coll,Wuhan 430030,Peoples R China[3]Hubei Clin Res Ctr Nasal Inflammatory Dis, Wuhan 430030, Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Otolaryngol Head & Neck Surg,Wuhan 430030,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Hosp,Inst Allergy & Clin Immunol,Tongji Med Coll,Wuhan 430030,Peoples R China[3]Hubei Clin Res Ctr Nasal Inflammatory Dis, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Li Min-shan,Wang Xiang-hong,Wang Heng.Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation[J].CURRENT MEDICAL SCIENCE.2024,doi:10.1007/s11596-024-2872-4.
APA：
Li, Min-shan,Wang, Xiang-hong&Wang, Heng.(2024).Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation.CURRENT MEDICAL SCIENCE,,
MLA：
Li, Min-shan,et al."Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation".CURRENT MEDICAL SCIENCE .(2024)
