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Hypoxia-inducible PRMT2 addiction in glioblastomas

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Dong Feng[1,2] * ; Sun Xiaoyu[2] * ; Su Jiacheng[2] ; Li Qian[2] ; He You[2] ; Li Wei[3] ; Wang Baofeng[4] ; Wang Bo[5] ; Xu Guogang[6] ; Wu Xudong[1,2,7] ;
单位： [1]State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, School of Biomedical Engineering & Technology, Tianjin Medical University, Tianjin 300070, China [2]Department of Cell Biology, Tianjin Medical University, Qixiangtai Road 22, Tianjin 300070, China [3]Department of Pathology, Tianjin First Central Hospital, Tianjin 300192, China [4]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China [5]Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative diseases, Tianjin Neurosurgical Institute, No. 6 Jizhao Road, Tianjin 300350, China [6]Health Management Institute, The Second Medical Center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China [7]Department of Neurosurgery, Tianjin Medical University General Hospital and Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052, China
出处：
DOI： 10.1016/j.cellsig.2024.111094
ISSN：

关键词： Hypoxia Protein arginine methyltransferase 2 Histone arginine methylation Transcription Glioblastoma

摘要：
Hypoxia-inducible transcription factors (HIFs) are key transcription factors for cellular response to low oxygen levels. However, the specific mediators responsible for activating downstream transcription are not well characterized. We previously identified Protein Arginine methyltransferase 2 (PRMT2), a highly expressed methyltransferase in glioblastoma multiforme, as a transcription co-activator. And we established a connection between PRMT2-mediated histone H3R8 asymmetric methylation (H3R8me2a) and transcription activation. Here we find that PRMT2 is activated by HIF1α under hypoxic conditions. And we demonstrate that PRMT2 and its H3R8me2a activity are required for the transcription activation of a significant subset of hypoxia-induced genes. Consequently, the inactivation of PRMT2 suppresses hypoxia-induced glioblastoma cell migration, attenuates tumor progression, and enhances chemotherapeutic sensitivity in mouse xenograft models. In addition, our analysis of clinical glioma specimens reveals a correlation between PRMT2 protein levels, HIF1α abundance, and an unfavorable prognosis. Our study establishes HIF1α-induced PRMT2 as a critical modulator in the activation of hypoxia-related transcriptional programs, ultimately driving malignant progression.Copyright © 2024. Published by Elsevier Inc.

基金：
This study was supported by the Key Research Project of Tianjin Education Commission (2020ZD13 to X.W.).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 生物学
小类 | 3 区 细胞生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 3 区 细胞生物学
JCR分区：
出版当年[2022]版：
Q2 CELL BIOLOGY
最新[2023]版：
Q2 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者单位： [1]State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, School of Biomedical Engineering & Technology, Tianjin Medical University, Tianjin 300070, China [2]Department of Cell Biology, Tianjin Medical University, Qixiangtai Road 22, Tianjin 300070, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, School of Biomedical Engineering & Technology, Tianjin Medical University, Tianjin 300070, China [2]Department of Cell Biology, Tianjin Medical University, Qixiangtai Road 22, Tianjin 300070, China [7]Department of Neurosurgery, Tianjin Medical University General Hospital and Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052, China
推荐引用方式(GB/T 7714)：
Dong Feng,Sun Xiaoyu,Su Jiacheng,et al.Hypoxia-inducible PRMT2 addiction in glioblastomas[J].Cellular Signalling.2024,117:111094.doi:10.1016/j.cellsig.2024.111094.
APA：
Dong Feng,Sun Xiaoyu,Su Jiacheng,Li Qian,He You...&Wu Xudong.(2024).Hypoxia-inducible PRMT2 addiction in glioblastomas.Cellular Signalling,117,
MLA：
Dong Feng,et al."Hypoxia-inducible PRMT2 addiction in glioblastomas".Cellular Signalling 117.(2024):111094

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