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Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Li Huan[1] * ; Song Chao[1] ; Zhang Yang[1] ; Liu Guohao[2] ; Mi Hailong[1] ; Li Yachao[1] ; Chen Zhiye[2] ; Ma Xiaoyu[2] ; Zhang Po[2] ; Cheng Lidong[2] ; Peng Peng[2] ; Zhu Hongtao[2] ; Chen Zirong[2] ; Dong Minhai[2] ; Chen Sui[2] ; Meng Hao[3] ; Xiao QunGen[2] ; Li Honglian[1] ; Wu Qiulian[4] ; Wang Baofeng[2] ; Zhang Suojun[2] ; Shu Kai[2] ; Wan Feng[2] ; Guo Dongsheng[2] ; Zhou Wenchao[3] ; Zhou Lin[1] ; Mao Feng[2] ; Rich Jeremy N[4,5] ; Yu Xingjiang[1] ;
单位： [1]Department of Histology and Embryology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. [2]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. [3]Intelligent Pathology Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230031, China. [4]UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 15219, USA. [5]Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
出处：
DOI： 10.1002/advs.202305620
ISSN：

关键词： glioblastoma stem cells HDAC2 HIF1𝛼 Hypoxia natural borneol sodium valproate transgelin

摘要：
Glioblastoma (GBM) is a lethal cancer characterized by hypervascularity and necrosis associated with hypoxia. Here, it is found that hypoxia preferentially induces the actin-binding protein, Transgelin (TAGLN), in GBM stem cells (GSCs). Mechanistically, TAGLN regulates HIF1α transcription and stabilizes HDAC2 to deacetylate p53 and maintain GSC self-renewal. To translate these findings into preclinical therapeutic paradigm, it is found that sodium valproate (VPA) is a specific inhibitor of TAGLN/HDAC2 function, with augmented efficacy when combined with natural borneol (NB) in vivo. Thus, TAGLN promotes cancer stem cell survival in hypoxia and informs a novel therapeutic paradigm.© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

基金：
The authors thank Dr. Shideng Bao for providing the GSC and NPC cell lines used in this study and Dr. Lin Zhou for her assistance in this study. The authors also thank the Neurosurgery Department of Tongji Medical College for providing the human GBM tissues for this study. This work was supported by the Program for the HUST Academic Frontier Youth Team, the Huazhong University of Science and Technology Independent Innovation Research Fund Project (No. 2019kfyXJJS187), National Natural Science Foundation of China (No. 82072805), Natural Science Foundation of Hubei Province (No. 2020CFB678), and The Anhui Provincial Natural Science Foundation grant (No. 2108085J43) to W. Zhou.
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 材料科学
小类 | 1 区 化学：综合 1 区 材料科学：综合 2 区 纳米科技
最新[2025]版：
大类 | 1 区 综合性期刊
小类 | 1 区 化学：综合 1 区 材料科学：综合 1 区 纳米科技
JCR分区：
出版当年[2022]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY
最新[2023]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者单位： [1]Department of Histology and Embryology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
通讯作者：
通讯机构： [4]UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 15219, USA. [5]Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
推荐引用方式(GB/T 7714)：
Li Huan,Song Chao,Zhang Yang,et al.Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation[J].ADVANCED SCIENCE.2024,11(7):doi:10.1002/advs.202305620.
APA：
Li Huan,Song Chao,Zhang Yang,Liu Guohao,Mi Hailong...&Yu Xingjiang.(2024).Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation.ADVANCED SCIENCE,11,(7)
MLA：
Li Huan,et al."Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation".ADVANCED SCIENCE 11..7(2024)

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