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Mitochondria in Mesenchymal Stem Cells: Key to Fate Determination and Therapeutic Potential

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收录情况： ◇ SCIE

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单位： [1]Department of Gynecological Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China. [2]National Clinical Research Center for Obstetrics and Gynecology,Cancer Biology Research Center (Key Laboratory of the Ministry of Education),Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China. [3]Reproductive Medicine Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.

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关键词： Mesenchymal stem cells Mitochondria Regenerative therapy Mitochondrial morphology Signal transduction Mitochondrial transfer

摘要：

Mesenchymal stem cells (MSCs) have become popular tool cells in the field of transformation and regenerative medicine due to their function of cell rescue and cell replacement. The dynamically changing mitochondria serve as an energy metabolism factory and signal transduction platform, adapting to different cell states and maintaining normal cell activities. Therefore, a clear understanding of the regulatory mechanism of mitochondria in MSCs is profit for more efficient clinical transformation of stem cells. This review highlights the cutting-edge knowledge regarding mitochondrial biology from the following aspects: mitochondrial morphological dynamics, energy metabolism and signal transduction. The manuscript mainly focuses on mitochondrial mechanistic insights in the whole life course of MSCs, as well as the potential roles played by mitochondria in MSCs treatment of transplantation, for seeking pivotal targets of stem cell fate regulation and stem cell therapy.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区细胞与组织工程 3 区细胞生物学 3 区医学：研究与实验

最新[2025]版：

大类 | 3 区医学

小类 | 3 区细胞与组织工程 3 区细胞生物学 3 区医学：研究与实验

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出版当年[2022]版：

Q2 CELL & TISSUE ENGINEERING Q2 CELL BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q2 CELL & TISSUE ENGINEERING Q2 CELL BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 4.5 最新[2023版] 4.7 最新五年平均 4.8 出版当年[2022版] 4.7 出版当年五年平均 6.692 出版前一年[2021版] 4.5 出版后一年[2023版]

第一作者：

第一作者单位： [1]Department of Gynecological Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China. [2]National Clinical Research Center for Obstetrics and Gynecology,Cancer Biology Research Center (Key Laboratory of the Ministry of Education),Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.

通讯作者：

通讯机构： [1]Department of Gynecological Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China. [2]National Clinical Research Center for Obstetrics and Gynecology,Cancer Biology Research Center (Key Laboratory of the Ministry of Education),Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China. [3]Reproductive Medicine Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.

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