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Exploring potential genes and mechanisms linking erectile dysfunction and depression

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单位： [1]Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [2]Department of Urology Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China. [3]Reproductive Medicine Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China.

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关键词： erectile dysfunction depression biomarker shared transcriptome bioinformatics

摘要：

The clinical correlation between erectile dysfunction (ED) and depression has been revealed in cumulative studies. However, the evidence of shared mechanisms between them was insufficient. This study aimed to explore common transcriptomic alterations associated with ED and depression.The gene sets associated with ED and depression were collected from the Gene Expression Omnibus (GEO) database. Comparative analysis was conducted to obtain common genes. Using R software and other appropriate tools, we conducted a range of analyses, including function enrichment, interactive network creation, gene cluster analysis, and transcriptional and post-transcriptional signature profiling. Candidate hub crosslinks between ED and depression were selected after external validation and molecular experiments. Furthermore, subpopulation location and disease association of hub genes were explored.A total of 85 common genes were identified between ED and depression. These genes strongly correlate with cell adhesion, redox homeostasis, reactive oxygen species metabolic process, and neuronal cell body. An interactive network consisting of 80 proteins and 216 interactions was thereby developed. Analysis of the proteomic signature of common genes highlighted eight major shared genes: CLDN5, COL7A1, LDHA, MAP2K2, RETSAT, SEMA3A, TAGLN, and TBC1D1. These genes were involved in blood vessel morphogenesis and muscle cell activity. A subsequent transcription factor (TF)-miRNA network showed 47 TFs and 88 miRNAs relevant to shared genes. Finally, CLDN5 and TBC1D1 were well-validated and identified as the hub crosslinks between ED and depression. These genes had specific subpopulation locations in the corpus cavernosum and brain tissue, respectively.Our study is the first to investigate common transcriptomic alterations and the shared biological roles of ED and depression. The findings of this study provide insights into the referential molecular mechanisms underlying the co-existence between depression and ED.Copyright © 2023 Yuan, Chen, Sun, Cui, Wei, Li and Meng.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区内分泌学与代谢

最新[2025]版：

大类 | 3 区医学

小类 | 3 区内分泌学与代谢

JCR分区：

出版当年[2021]版：

Q1 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q2 ENDOCRINOLOGY & METABOLISM

影响因子： 3.9 最新[2023版] 4.9 最新五年平均 6.055 出版当年[2021版] 6.335 出版当年五年平均 5.555 出版前一年[2020版] 5.2 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [2]Department of Urology Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China.

通讯作者：

通讯机构： [1]Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [2]Department of Urology Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China.

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Exploring potential genes and mechanisms linking erectile dysfunction and depression

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