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Healthy dietary patterns, genetic risk, and gastrointestinal cancer incident risk: a large-scale prospective cohort study

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收录情况： ◇ SCIE

作者：
Cai Yimin[1] * ; Hong Canlin[2] * ; Han Jinxin[3] * ; Fan Linyun[2] * ; Xiao Xinyu[2] * ; Xiao Jun[4] * ; Wei Yongchang[5] ; Zhu Ying[2] ; Tian Jianbo[6] ; Zhu Xu[7] ; Jin Meng[8] ; Miao Xiaoping[9] ;
单位： [1]Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [2]Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan, Hubei, China. [3]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [4]Department of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [5]Department of Gastrointestinal Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. [6]Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan, Hubei, China. [7]Department of Gastrointestinal Surgery, Renmin Hospital, Wuhan University, Wuhan, Hubei, China. [8]Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [9]Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China [10]Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan, Hubei, China.
出处：
DOI： 10.1016/j.ajcnut.2023.11.015
ISSN：

关键词： gastrointestinal cancer dietary patterns genetic risk gene-diet interaction

摘要：
Dietary patterns have been associated with several cancers, especially gastrointestinal cancer (GIC). However, whether a healthy dietary pattern could modify the risk of GIC among people with different genetic backgrounds is not clear.The objective of the study was to investigate how dietary patterns and genetic susceptibility contribute to the risk of GIC independently and jointly.This large-scale prospective cohort study included 105,463 participants in UK Biobank who were aged 40-72 y and cancer-free at baseline. Dietary intake (Oxford WebQ) was used to calculate dietary pattern scores including dietary approach to stop hypertension (DASH) score and healthful plant-based diet index (hPDI). Genetic risk was quantified by a polygenic risk score (PRS) comprising 129 known GIC-associated loci. Cox proportional hazards regression was performed to estimate the associations of dietary patterns and PRS with GIC incidence after adjusting for potential confounders.Over a median follow-up of 11.7 y, 1661 participants were diagnosed with GIC. DASH and hPDI were associated with 20% and 36% reductions, respectively, in GIC risk. Low PRS was associated with a 0.70-fold decrease in GIC risk (HR: 0.70; 95% CI: 0.62, 0.79). Participants with healthy dietary scores at high-genetic risk had a lower GIC risk with the HR of 0.77 (95% CI: 0.60, 0.98) for DASH and 0.66 (95% CI: 0.52, 0.84) for hPDI than those with unhealthy dietary score. Participants with both high-dietary score and low-genetic risk showed the lowest risk of GIC, with HR of 0.58 (95% CI: 0.45, 0.75) for DASH and 0.45 (95% CI: 0.34, 0.58) for hPDI.Adherence to DASH and hPDI were associated with a lower risk of some gastrointestinal cancers, and these 2 dietary patterns may partly compensate for genetic predispositions to cancer. Our results support the development of precision medicine strategies that consider both dietary patterns and genetics to improve gastrointestinal health.Copyright © 2023 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.

基金：
This work was supported by the Key Program of National Natural Science Foundation of China (NSFC-82130098) for Xiaoping Miao; the Fundamental Research Funds for the Central Universities (WHU:2042022kf1205) and the Knowledge Innovation Program of Wuhan (whkxjsj011) for Jianbo Tian.
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 营养学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 营养学
JCR分区：
出版当年[2022]版：
Q1 NUTRITION & DIETETICS
最新[2023]版：
Q1 NUTRITION & DIETETICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者单位： [1]Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Cai Yimin,Hong Canlin,Han Jinxin,et al.Healthy dietary patterns, genetic risk, and gastrointestinal cancer incident risk: a large-scale prospective cohort study[J].AMERICAN JOURNAL OF CLINICAL NUTRITION.2024,119(2):406-416.doi:10.1016/j.ajcnut.2023.11.015.
APA：
Cai Yimin,Hong Canlin,Han Jinxin,Fan Linyun,Xiao Xinyu...&Miao Xiaoping.(2024).Healthy dietary patterns, genetic risk, and gastrointestinal cancer incident risk: a large-scale prospective cohort study.AMERICAN JOURNAL OF CLINICAL NUTRITION,119,(2)
MLA：
Cai Yimin,et al."Healthy dietary patterns, genetic risk, and gastrointestinal cancer incident risk: a large-scale prospective cohort study".AMERICAN JOURNAL OF CLINICAL NUTRITION 119..2(2024):406-416

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