单位：[1]Division of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.内科学系大内科心血管内科华中科技大学同济医学院附属同济医院[2]Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan 430030, China.[3]Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.华中科技大学同济医学院附属同济医院
Liquid-liquid phase separation (LLPS) is a biophysical process that mediates the precise and complex spatiotemporal coordination of cellular processes. Proteins and nucleic acids are compartmentalized into micron-scale membrane-less droplets via LLPS. These droplets, termed biomolecular condensates, are highly dynamic, have concentrated components, and perform specific functions. Biomolecular condensates have been observed to organize diverse key biological processes, including gene transcription, signal transduction, DNA damage repair, chromatin organization, and autophagy. The dysregulation of these biological activities owing to aberrant LLPS is important in cardiovascular diseases. This review provides a detailed overview of the regulation and functions of biomolecular condensates, provides a comprehensive depiction of LLPS in several common cardiovascular diseases, and discusses the revolutionary therapeutic perspective of modulating LLPS in cardiovascular diseases and new treatment strategies relevant to LLPS.
基金：
This study was funded by the National Key Research and Development Program of China(grant numbers:2021YFC2500600, 2021YFC2500604), the National Natural Science Foundation ofChina (grant numbers:82170392, 81974047, and 81670215), and the Natural Science Foundation ofHubei Province (grant number: 2021BCA121).
第一作者单位：[1]Division of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.[2]Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan 430030, China.
共同第一作者：
通讯作者：
通讯机构：[1]Division of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.[2]Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan 430030, China.[3]Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
推荐引用方式(GB/T 7714)：
Cai Ziyang,Mei Shuai,Zhou Li,et al.Liquid-Liquid Phase Separation Sheds New Light upon Cardiovascular Diseases[J].INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2023,24(20):doi:10.3390/ijms242015418.
APA：
Cai Ziyang,Mei Shuai,Zhou Li,Ma Xiaozhu,Wuyun Qidamugai...&Ding Hu.(2023).Liquid-Liquid Phase Separation Sheds New Light upon Cardiovascular Diseases.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24,(20)
MLA：
Cai Ziyang,et al."Liquid-Liquid Phase Separation Sheds New Light upon Cardiovascular Diseases".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24..20(2023)
生物学