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Intravenous immunoglobulin in kidney transplantation: Mechanisms of action, clinical applications, adverse effects, and hyperimmune globulin

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收录情况： ◇ SCIE

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单位： [1]Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology.Key Laboratory of Organ Transplantation,Ministry of Education. NHC Key Laboratory of Organ Transplantation.Key Laboratory of Organ Transplantation,Chinese Academy of Medical Sciences,Wuhan 430030,China

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关键词： Intravenous immunoglobulin Kidney transplantation Mechanism of action Hyperimmune globulin Adverse effect

摘要：

Intravenous immunoglobulin (IVIG) has been developed for over 40 years. The mechanisms of action of IVIG are complex and diverse, and there may be multiple mechanisms that combine to influence it. IVIG has been used in kidney transplantation for desensitization, treatment of antibody-mediated rejection, and ABO-incompatible transplantation. and treatment or prevention of some infectious diseases. Hyperimmune globulins such as cytomegalovirus hyperimmune globulin (CMV-IG) and hepatitis B hyperimmune globulin (HBIG) have also been used to protect against cytomegalovirus and hepatitis B virus, respectively. However, IVIG is also associated with some rare but serious adverse effects and some application risks, and clinicians need to weigh the pros and cons and develop individualized treatment programs to benefit more patients. This review will provide an overview of the multiple mechanisms of action, clinical applications, adverse effects, and prophylactic measures of IVIG, and hyperimmune globulin will also be introduced in it.Copyright © 2023. Published by Elsevier Inc.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区免疫学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区免疫学

JCR分区：

出版当年[2021]版：

Q1 IMMUNOLOGY

最新[2023]版：

Q2 IMMUNOLOGY

影响因子： 4.5 最新[2023版] 4.7 最新五年平均 10.19 出版当年[2021版] 6.592 出版当年五年平均 3.969 出版前一年[2020版] 8.6 出版后一年[2022版]

第一作者：

第一作者单位： [1]Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology.Key Laboratory of Organ Transplantation,Ministry of Education. NHC Key Laboratory of Organ Transplantation.Key Laboratory of Organ Transplantation,Chinese Academy of Medical Sciences,Wuhan 430030,China

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