单位：[1]Department of Biliary-Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.外科学系胆胰外科华中科技大学同济医学院附属同济医院[2]Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway. The TGF-β pathway is widely known for its dual role in cancer progression as both an inhibitor of tumour cell growth and an inducer of tumour metastasis. This is mainly mediated through SMAD proteins and their cofactors or regulators. SMAD proteins act as transcription factors, regulating the transcription of a wide range of genes, and their rich post-translational modifications are influenced by a variety of regulators and cofactors. The complex role, mechanisms, and important functions of SMAD proteins in tumours are the hot topics in current oncology research. In this paper, we summarize the recent progress on the effects and mechanisms of SMAD proteins on tumour development, diagnosis, treatment and prognosis, and provide clues for subsequent research on SMAD proteins in tumours.
基金：
National Natural Science Foundation of China (grant
numbers 81572783, 81974438, and 82173069 to Y.C.), the Zhejiang Provincial Natural Science Foundation (grant numbers LQ23C060003 to Y.Q.), and the Zhejiang Medicine and Health Science and
Technology Project (grant numbers 2023KY124 to Y.Q.).
第一作者单位：[1]Department of Biliary-Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Qi,Xiong Fei,Wu Guanhua,et al.SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications[J].DIAGNOSTICS.2023,13(17):doi:10.3390/diagnostics13172769.
APA：
Wang Qi,Xiong Fei,Wu Guanhua,Wang Da,Liu Wenzheng...&Chen Yongjun.(2023).SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications.DIAGNOSTICS,13,(17)
MLA：
Wang Qi,et al."SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications".DIAGNOSTICS 13..17(2023)
