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Animal models for anti-neutrophil cytoplasmic antibody-associated vasculitis: Are current models good enough?

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单位： [1]Department of Geriatrics,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China. [2]Department of General Medicine,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China. [3]Department of Nephrology,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China. [4]Department of health management center,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China. [5]Interdisciplinary Sciences Institute, Huazhong Agricultural University, Wuhan, China. [6]State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

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关键词： antineutrophil cytoplasmic antibody experimental models pathogenesis vasculitis

摘要：

Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a rare and severe systemic autoimmune disease characterized by pauci-immune necrotizing inflammation of small blood vessels. AAV involves multiple organ systems throughout the body. Our knowledge of the pathogenesis of AAV has increased considerably in recent years, involving cellular, molecular and genetic factors. Because of the controlled environment with no other confounding factors, animal models are beneficial for studying the mechanistic details of disease development and for providing novel therapeutic targets with fewer toxic side effects. However, the complexity and heterogeneity of AAV make it very difficult to establish a single animal model that can fully represent the entire clinical spectrum found in patients. The aim of this review is to overview the current status of animal models for AAV, outline the pros and cons of methods, and propose potential directions for future research.© 2023 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.

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最新[2025]版：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 2 区医学：研究与实验

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无

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 3.8 最新[2023版] 3.5 最新五年平均 0 出版当年[2021版] 0 出版当年五年平均 0 出版前一年[2020版] 3.7 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department of Geriatrics,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China. [2]Department of General Medicine,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China.

通讯作者：

通讯机构： [5]Interdisciplinary Sciences Institute, Huazhong Agricultural University, Wuhan, China. [6]State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

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Animal models for anti-neutrophil cytoplasmic antibody-associated vasculitis: Are current models good enough?

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