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Association of Healthy Sleep Pattern with Risk of Recurrent Cardiovascular Events among Patients with Coronary Heart Disease

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单位: [1]Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, and State Key Laboratory of Environment Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Department of Applied Statistics, Johannes Kepler Universität Linz, Linz, Austria. [3]Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai, China. [4]Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [5]Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [6]Department of Endocrinology, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, China. [7]Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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关键词: Coronary heart disease  Sleep pattern  Cardiovascular event  Cohort

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To examine the association of a healthy sleep pattern with the risk of recurrent cardiovascular events among patients with coronary heart disease (CHD).This prospective cohort study included 21 193 individuals with CHD from the UK Biobank. A healthy sleep score was generated based on a combination of chronotype, sleep duration, insomnia, and excessive daytime sleepiness. Cox proportional hazards regression models were applied to estimate the associations between healthy sleep score and recurrent cardiovascular events. During a median of 11.1 years of follow up, we documented 3 771 recurrent cardiovascular events including 1 634 heart failure cases and 704 stroke cases. After multivariable adjustment including lifestyle factors, medical history, and CHD duration, sleep 7-8 h/day, never/rarely insomnia, and no frequent daytime sleepiness were each significantly associated with a 12%-22% lower risk of heart failure. In addition, compared with participants who had a healthy sleep score of 0-1, the multivariable-adjusted HR (95% CI) for participants with a healthy sleep score of 4 was 0.86 (0.75, 0.99) for recurrent cardiovascular events, 0.71 (0.57, 0.89) for heart failure, and 0.72 (0.51, 1.03) for stroke.Adherence to a healthy sleep pattern was significantly associated with a lower risk of recurrent cardiovascular events among patients with CHD, especially for heart failure. These findings indicate that healthy sleep behaviors could be beneficial in the prevention of cardiovascular event recurrence.© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.

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出版当年[2022]版:
大类 | 2 区 医学
小类 | 2 区 心脏和心血管系统
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大类 | 2 区 医学
小类 | 2 区 心脏和心血管系统
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出版当年[2021]版:
Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
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Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

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第一作者单位: [1]Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, and State Key Laboratory of Environment Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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