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The roles of the Hippo-YAP signalling pathway in Cartilage and Osteoarthritis

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Sun Kai[1] * ; Guo Jiachao[2] * ; Guo Zhou[1] ; Hou Liangcai[1] ; Liu Haigang[1] ; Hou Yanjun[1] ; He Junchen[1] ; Guo Fengjing[1] ; Ye Yaping[1] ;
单位： [1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China. [2]Department of Pediatric Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China
出处：
DOI： 10.1016/j.arr.2023.102015
ISSN：

关键词： Osteoarthritis Cartilage Hippo YAP TAZ

摘要：
Osteoarthritis (OA) is an age-related disease, characterized by cartilage degeneration. The pathogenesis of OA is complicated and the current therapeutic approaches for OA are limited. Cartilage, an integral part of the skeletal system composed of chondrocytes, is essential for skeletal development, tissue patterning, and maintaining the normal activity of joints. The development, homeostasis and degeneration of cartilage are tightly associated with OA. Over the past decade, accumulating evidence indicates that Hippo/YAP is a vital biochemical signalling pathway that strictly governs tissue development and homeostasis. The joint tissues, especially for cartilage, are sensitive to changes of Hippo/YAP signalling. In this review, we summarize the role of Hippo/YAP signalling in cartilage and discuss its involvement in OA progression from points of cartilage degradation, subchondral bone remodeling, and synovial alteration. We also highlight the potential therapeutic implications of Hippo/YAP signalling and further discuss current limitations and controversy on Hippo/YAP-based application for OA treatment.Copyright © 2023. Published by Elsevier B.V.

基金：
National Natural Science Foundation of China [no. 82172498], [no. 82172435], and [no. 82102625].
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 老年医学 2 区 细胞生物学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 老年医学 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 CELL BIOLOGY Q1 GERIATRICS & GERONTOLOGY
最新[2023]版：
Q1 CELL BIOLOGY Q1 GERIATRICS & GERONTOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Sun Kai,Guo Jiachao,Guo Zhou,et al.The roles of the Hippo-YAP signalling pathway in Cartilage and Osteoarthritis[J].AGEING RESEARCH REVIEWS.2023,90:doi:10.1016/j.arr.2023.102015.
APA：
Sun Kai,Guo Jiachao,Guo Zhou,Hou Liangcai,Liu Haigang...&Ye Yaping.(2023).The roles of the Hippo-YAP signalling pathway in Cartilage and Osteoarthritis.AGEING RESEARCH REVIEWS,90,
MLA：
Sun Kai,et al."The roles of the Hippo-YAP signalling pathway in Cartilage and Osteoarthritis".AGEING RESEARCH REVIEWS 90.(2023)

相关文献

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