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The emerging role of circadian rhythms in the development and function of thermogenic fat

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单位: [1]Division of Endocrinology, Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China [2]Laboratory of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China [3]Branch of National Clinical Research Center for Metabolic Diseases, Hubei, China
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关键词: brown/beige fat circadian rhythms obesity thermogenesis circadian clock

摘要:
Circadian rhythms regulate many biological processes in response to ambient influences. A disrupted circadian rhythm has been shown to be associated with obesity and obesity-related metabolic disorders. Thermogenic fat, including brown and beige fat, may play an important role in this process since it displays a high capacity to burn fat and release the stored energy as heat, contributing to the combat against obesity and its associated metabolic disorders. In this review, we summarize the relationship between the circadian clock and thermogenic fat and the prominent mechanisms which are involved in the regulation of the development and function of thermogenic fat by circadian rhythms, which may provide novel therapeutics for the prevention and treatment of metabolic diseases by targeting thermogenic fat in a circadian manner.Copyright © 2023 Peng and Chen.

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出版当年[2022]版:
大类 | 2 区 医学
小类 | 2 区 内分泌学与代谢
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 内分泌学与代谢
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出版当年[2021]版:
Q1 ENDOCRINOLOGY & METABOLISM
最新[2023]版:
Q2 ENDOCRINOLOGY & METABOLISM

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第一作者单位: [1]Division of Endocrinology, Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China [2]Laboratory of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
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通讯机构: [1]Division of Endocrinology, Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China [2]Laboratory of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China [3]Branch of National Clinical Research Center for Metabolic Diseases, Hubei, China
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