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Potential genetic therapies based on m6A methylation for skin regeneration: Wound healing and scars/keloids

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收录情况： ◇ SCIE

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单位： [1]Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [3]Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

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关键词： m6A methylation skin regeneration wound healing scars keloids

摘要：

Skin wound healing is a complex and multistage process, where any abnormalities at any stage can result in the accumulation of non-functional fibrotic tissue, leading to the formation of skin scars. Epigenetic modifications play a crucial role in regulating gene expression, inhibiting cell fate determination, and responding to environmental stimuli. m6A methylation is the most common post-transcriptional modification of eukaryotic mRNAs and long non-coding RNAs. However, it remains unclear how RNA methylation controls cell fate in different physiological environments. This review aims to discuss the current understanding of the regulatory pathways of RNA methylation in skin wound healing and their therapeutic implications with a focus on the specific mechanisms involved.Copyright © 2023 Luo, Zhu, Li, Zeng, Wang, Wu, Wang and Liu.

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出版当年[2022]版：

大类 | 2 区工程技术

小类 | 3 区综合性期刊

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生物工程与应用微生物 4 区工程：生物医学

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出版当年[2021]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 ENGINEERING, BIOMEDICAL

影响因子： 4.3 最新[2023版] 5.1 最新五年平均 6.064 出版当年[2021版] 6.303 出版当年五年平均 5.89 出版前一年[2020版] 5.7 出版后一年[2022版]

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第一作者单位： [1]Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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