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Long-term Consequences of COVID-19: Chemosensory Disorders

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单位: [1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Otolaryngol Head & Neck Surg,1095 Jiefang Ave,Wuhan 430030,Peoples R China [2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Insititue Allergy & Clin Immunol,Wuhan,Peoples R China [3]Hubei Clin Res Ctr Nasal Inflammatory Dis, Wuhan, Peoples R China
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关键词: Olfactory dysfunction Gustatory dysfunction Recovery Long COVID-19

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Purpose of Review A number of sequelae after acute coronavirus disease 2019 (COVID-19) significantly affect the quality of life of patients. The chemosensory disorders including olfactory dysfunction (OD) and gustatory dysfunction (GD) are two of the commonest symptoms complained by patients with COVID-19. Although chemosensory function has been reported improved in over 60% of COVID-19 patients in a short time after acute infection, it may last as a major symptom for patients with long COVID-19. This narrative review discussed current literatures on OD and GD in long COVID-19 including the prevalence, risk factors, possible mechanisms, and potential therapies. Recent Findings Although the prevalence of OD and GD has declined continuously after acute COVID-19, a considerable number of patients had persistent chemosensory disorders 3 months to 2 years after symptom onset. Female gender, initial severity of dysfunction, nasal congestion, emotional distress and depression, and SARS-CoV-2 variants have been identified as risk factors for persistent OD and GD in long COVID-19. The pathogenesis of OD and GD in long COVID-19 remains unknown, but may be analogous to the persistent OD and GD post common respiratory viral infection. Corticosteroids and olfactory training might be a potential choice regarding the treatment of lasting OD and GD after SARS-CoV-2 infection; however, more studies are needed to prove it. Summary OD and GD are common long-term consequences of COVID-19 and influenced by gender, initial severity of dysfunction, emotional distress and depression, and SARS-CoV-2 variants. More studies are needed to illustrate their pathogenesis and to establish therapeutic strategies.

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出版当年[2022]版
大类 | 2 区 医学
小类 | 2 区 免疫学 3 区 过敏
最新[2025]版
大类 | 2 区 医学
小类 | 2 区 过敏 2 区 免疫学
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Q2 IMMUNOLOGY Q3 ALLERGY
最新[2023]版:
Q1 ALLERGY Q1 IMMUNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者单位: [1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Otolaryngol Head & Neck Surg,1095 Jiefang Ave,Wuhan 430030,Peoples R China [2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Insititue Allergy & Clin Immunol,Wuhan,Peoples R China [3]Hubei Clin Res Ctr Nasal Inflammatory Dis, Wuhan, Peoples R China
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通讯机构: [1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Otolaryngol Head & Neck Surg,1095 Jiefang Ave,Wuhan 430030,Peoples R China [2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Insititue Allergy & Clin Immunol,Wuhan,Peoples R China [3]Hubei Clin Res Ctr Nasal Inflammatory Dis, Wuhan, Peoples R China
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