B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.
第一作者单位：[1]Huazhong Univ Sci Technol, Tongji Med Coll, Sch Basic Med, Dept Pathogen Biol, Wuhan, Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Internal Med, Div Gastroenterol & Hepatol, Wuhan, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Shiru,Guan Fei,Candotti Fabio,et al.The role of B cells in COVID-19 infection and vaccination[J].FRONTIERS IN IMMUNOLOGY.2022,13:doi:10.3389/fimmu.2022.988536.
APA：
Chen, Shiru,Guan, Fei,Candotti, Fabio,Benlagha, Kamel,Camara, Niels Olsen Saraiva...&Liu, Chaohong.(2022).The role of B cells in COVID-19 infection and vaccination.FRONTIERS IN IMMUNOLOGY,13,
MLA：
Chen, Shiru,et al."The role of B cells in COVID-19 infection and vaccination".FRONTIERS IN IMMUNOLOGY 13.(2022)
医学