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Association of selenium profile with neutralizing antibody response to inactivated SARS-CoV-2 vaccination

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收录情况： ◇ SCIE

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单位： [1]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Zhuhai Precision Medical Center, Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China [3]Department of Nutrition, Hygiene and Toxicology, Academy of Nutrition and Health, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China

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关键词： Selenium profile SARS-CoV-2 Vaccine Neutralizing antibody

摘要：

Selenium profile has been related with humoral immune response after vaccination, but evidence with regard to inactivated SARS-CoV-2 vaccine is lacking.The current study aimed to examine the relationship between selenium profile and neutralizing antibody response to inactivated SARS-CoV-2 vaccine.Plasma selenium and selenoprotein P concentrations, neutralizing antibody against the wild-type and Omicron variant were measured at baseline and at 14 days, 98 days after the third dose of inactivated SARS-CoV-2 vaccine.Neutralizing antibody against the wild-type and Omicron variant increased significantly after the third vaccination dose. Both higher plasma selenium and selenoprotein P were associated with increased neutralizing antibody against the wild-type strain at baseline. Moreover, higher plasma selenoprotein P was associated with increased neutralizing antibody against Omicron variant at baseline. However, nonsignificant association were observed after the third vaccine dose.Higher selenium profile was associated with neutralizing antibody response before the third dose of inactivated SARS-CoV-2 vaccine, but not after the third dose. Further prospective cohort studies are warranted to confirm our findings.Copyright © 2023 Elsevier GmbH. All rights reserved.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区内分泌学与代谢 3 区生化与分子生物学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区内分泌学与代谢

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出版当年[2021]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 ENDOCRINOLOGY & METABOLISM

影响因子： 3.6 最新[2023版] 3.6 最新五年平均 3.995 出版当年[2021版] 4.001 出版当年五年平均 3.849 出版前一年[2020版] 3.5 出版后一年[2022版]

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第一作者单位： [1]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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