Cardiac fibrosis is a significant global health problem associated with almost all types of heart disease. Extensive cardiac fibrosis reduces tissue compliance and contributes to adverse outcomes, such as cardiomyocyte hypertrophy, cardiomyocyte apoptosis, and even heart failure. It is mainly associated with pathological myocardial remodeling, characterized by the excessive deposition of extracellular matrix (ECM) proteins in cardiac parenchymal tissues. In recent years, a growing body of evidence demonstrated that microRNAs (miRNAs) have a crucial role in the pathological development of cardiac fibrosis. More than sixty miRNAs have been associated with the progression of cardiac fibrosis. In this review, we summarized potential miRNAs and miRNAs-related regulatory mechanisms for cardiac fibrosis and discussed the potential clinical application of miRNAs in cardiac fibrosis.
基金：
National Natural Science Foundation of China [81700300]; Innovation Team Fund Project of Hubei Province [WJ2021C001]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Inst Organ Transplantat,Wuhan 430030,Peoples R China[2]Minist Educ, Key Lab Organ Transplantat, Wuhan 430030, Peoples R China[3]NHC Key Lab Organ Transplantat, Wuhan 430030, Peoples R China[4]Chinese Acad Med Sci, Key Lab Organ Transplantat, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhao Yuanyuan,Du Dunfeng,Chen Shanshan,et al.New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies[J].GENES.2022,13(8):doi:10.3390/genes13081390.
APA：
Zhao, Yuanyuan,Du, Dunfeng,Chen, Shanshan,Chen, Zhishui&Zhao, Jiajia.(2022).New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies.GENES,13,(8)
MLA：
Zhao, Yuanyuan,et al."New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies".GENES 13..8(2022)
