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A TRPV1 common missense variant affected the prognosis of ischemic cardiomyopathy

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收录情况： ◇ SCIE

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单位： [1]Panzhihua Cent Hosp, Div Cardiol, Panzhihua, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Internal Med,Div Cardiol, Wuhan, Peoples R China [3]Huazhong Univ Sci & Technol, Hubei Key Lab Genet & Mol Mech Cardiol Disorders, Wuhan, Hubei, Peoples R China

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关键词： heart failure ischemic cardiomyopathy prognosis TRP whole exome sequencing

摘要：

The purpose was to identify the Transient receptor potential (TRP) superfamily gene variants associate with the prognosis of ischemic cardiomyopathy (ICM). A whole-exome sequencing study involving 252 ICM and 252 healthy controls participants enrolled from March 2003 to November 2017. Optimal sequence kernel association test and Cox regression dominant was conducted to identify the cause genes of TRP with ICM and association of common SNPs with prognosis of ICM. Rs224534 was verified in the replication population. Besides, the expression of TRPV1 was detectable in human failed heart ventricular tissues. The TRPs was not associated with the risk of ICM (P > .05). Rs224534 was significantly associated with the prognosis of ICM (Hazard ratio, 2.27, 95%CI: 1.31-3.94; P = 3.7 x 10(-3)), in the replication cohort, (hazard ratio 1.47, 95%CI: 1.04-2.07; P = 2.9 x 10(-2)), and in combined cohort hazard ratio 1.62 (95%CI: 1.21-2.18; P = 1.1 x 10(-3)). The common SNP of TRPV1 (rs224534) is associated with the prognosis of ICM, and homozygote rs224534-AA showed an unfavorable prognosis of ICM in the dominant model tested. Genotyping the variant may benefit to further progress judgment of ICM.

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出版当年[2021]版：

大类 | 4 区医学

小类 | 4 区医学：内科

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：内科

JCR分区：

出版当年[2020]版：

Q3 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q2 MEDICINE, GENERAL & INTERNAL

影响因子： 1.4 最新[2023版] 1.6 最新五年平均 1.889 出版当年[2020版] 2.351 出版当年五年平均 1.552 出版前一年[2019版] 1.817 出版后一年[2021版]

第一作者：

第一作者单位： [1]Panzhihua Cent Hosp, Div Cardiol, Panzhihua, Peoples R China [*1]Panzhihua Cent Hosp, 34 Yi Kang Ave, Panzhihua 617000, Peoples R China

通讯作者：

通讯机构： [1]Panzhihua Cent Hosp, Div Cardiol, Panzhihua, Peoples R China [*1]Panzhihua Cent Hosp, 34 Yi Kang Ave, Panzhihua 617000, Peoples R China

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