研究单位:[1]Huazhong University of Science and Technology[2]Hubei Cancer Hospital,Tongji Medical College,Huazhong University of Science and Technology Wuhan,Hubei,China,43000[3]Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology Wuhan,Hubei,China,430030[4]Jingjiang People' Hospital Jingjiang,Jiangsu,China,214500
研究目的:
Radiation pneumonitis is the main dose-limiting toxicity of thoracic radiotherapy, which can affect life quality, survival, and the tumor-controlling effects of patients receiving thoracic radiotherapy.
The purpose of this study is to:
Identify biomarkers including serum proteins, gene expression, genetic changes, and epigenetic modifications that determine radiation pneumonitis.
Investigate the relationship between radiation pneumonitis and other toxicities induced by radiotherapy.
Construct a predictive model for radiation pneumonitis.
Evaluate survival and treatment outcome of patients with radiation pneumonitis.