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A Multicenter Prospective Observational Study on Predictive Models and Clinical Outcome of Radiation Pneumonitis

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研究单位: [1]Huazhong University of Science and Technology [2]Hubei Cancer Hospital,Tongji Medical College,Huazhong University of Science and Technology Wuhan,Hubei,China,43000 [3]Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology Wuhan,Hubei,China,430030 [4]Jingjiang People' Hospital Jingjiang,Jiangsu,China,214500

研究目的:
Radiation pneumonitis is the main dose-limiting toxicity of thoracic radiotherapy, which can affect life quality, survival, and the tumor-controlling effects of patients receiving thoracic radiotherapy. The purpose of this study is to: Identify biomarkers including serum proteins, gene expression, genetic changes, and epigenetic modifications that determine radiation pneumonitis. Investigate the relationship between radiation pneumonitis and other toxicities induced by radiotherapy. Construct a predictive model for radiation pneumonitis. Evaluate survival and treatment outcome of patients with radiation pneumonitis.

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