A Study of LY3537982 Plus Immunotherapy With or Without Chemotherapy in Participants With Non-Small Cell Lung Cancer (NSCLC) With a Change in a Gene Called KRAS G12C
研究单位：[1]Eli Lilly and Company[2]Loxo Oncology, Inc.[3]Loxo Oncology, Inc.[4]The University of Arizona Cancer Center - North Campus,Tucson,Arizona,United States,85719[5]Mercy UC Davis Cancer Center,Merced,California,United States,95340[6]Millennium Oncology - Hollywood,Hollywood,Florida,United States,33024[7]University of Miami Hospital and Clinics, Sylvester Cancer Center,Miami,Florida,United States,33136[8]Miami Cancer Institute at Baptist Health, Inc.,Miami,Florida,United States,33176[9]Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala,Ocala,Florida,United States,34474[10]Comprehensive Hematology Oncology,Saint Petersburg,Florida,United States,33709[11]Tampa General Hospital,Tampa,Florida,United States,33606[12]Winship Cancer Institute, Emory University,Atlanta,Georgia,United States,30322[13]University of Illinois at Chicago,Chicago,Illinois,United States,60612[14]Boston Medical Center,Boston,Massachusetts,United States,02118[15]University of Michigan,Ann Arbor,Michigan,United States,48109[16]Cancer and Hematology Centers of Western Michigan,Grand Rapids,Michigan,United States,49503[17]Allina Health Cancer Institute,Minneapolis,Minnesota,United States,55407[18]Dartmouth-Hitchcock Medical Center,Lebanon,New Hampshire,United States,03756[19]Regional Cancer Care Associates,Freehold,New Jersey,United States,07728[20]Capital Health Medical Center - Hopewell,Pennington,New Jersey,United States,08534[21]The Valley Hospital,Ridgewood,New Jersey,United States,07450[22]Perlmutter Cancer Center at NYU Langone Hospital - Long Island,Mineola,New York,United States,11501[23]Laura and Isaac Perlmutter Cancer Center,New York,New York,United States,10016[24]Manhattan Eye, Ear and Throat Hospital,New York,New York,United States,10065[25]Memorial Sloan Kettering Cancer Center,New York,New York,United States,10065[26]Clinical Research Alliance,Westbury,New York,United States,11590[27]Asante Rogue Regional Medical Center,Medford,Oregon,United States,97504[28]Providence Portland Medical Center,Portland,Oregon,United States,97213[29]Tidelands Health Oncology,Murrells Inlet,South Carolina,United States,29576[30]William Beaumont Army Medical Center,Fort Bliss,Texas,United States,79918[31]Brooke Army Medical Center,Fort Sam Houston,Texas,United States,78234[32]The University of Vermont Medical Center Inc.,Burlington,Vermont,United States,05401[33]Kadlec Clinic Hematology and Oncology,Kennewick,Washington,United States,99336[34]Virginia Mason Medical Center,Seattle,Washington,United States,98101[35]VA Puget Sound Health Care System,Seattle,Washington,United States,98108[36]Icon Cancer Centre Wesley,Auchenflower,Queensland,Australia,4066[37]Goulburn Valley Health,Shepparton,Victoria,Australia,3630[38]Klinikum Klagenfurt am Wörthersee,Klagenfurt,Kärnten,Austria,9020[39]Landeskrankenhaus Feldkirch,Feldkirch,Vorarlberg,Austria,6800[40]Klinik Floridsdorf,Wien,Austria,1210[41]ZNA Middelheim,Antwerp,Antwerpen,Belgium,2020[42]AZ Sint-Maarten, Campus Leopoldstraat 2,Mechelen,Antwerpen,Belgium,2800[43]Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne,Yvoir,Namur,Belgium,5000[44]UZ Gent,Gent,Oost-Vlaanderen,Belgium,9000[45]Clinique Saint Pierre,Ottignies,Belgium,1340[46]AZ Glorieux Ronse,Ronse,Belgium,9600[47]Centro de Pesquisa Clínica do Instituto do Câncer do Ceará,Fortaleza,Ceará,Brazil,60430235[48]Sirio-Libanes Brasilia - Centro de Oncologia - Asa Sul,Brasilia,Distrito Federal,Brazil,70200-730[49]Hospital Brasilia,Lago sul,Distrito Federal,Brazil,71635580[50]Hospital São Domingos,Bequimao,Maranhão,Brazil,65060-645[51]Oncominas,Pouso Alegre,Minas Gerais,Brazil,37554-216[52]Hospital de Cancer de Londrina,Londrina,Paraná,Brazil,86015-520[53]Liga Norte Riograndense Contra o Câncer,Natal,Rio Grande Do Norte,Brazil,59062-000[54]ONCOSITE - Centro de Pesquisa Clinica em Oncologia,Ijui,Rio Grande Do Sul,Brazil,98700-000[55]Faculdade de Medicina do ABC,Santo André,São Paulo,Brazil,09060-650[56]Hospital Paulistano,Sao Paulo,São Paulo,Brazil,01321-001[57]COE Ensino e Pesquisa,São José dos Campos,São Paulo,Brazil,12242-660[58]Hospital São Lucas da PUCRS,Porto Alegre,Brazil,90610[59]Instituto Nacional de Câncer - INCA,Rio de Janeiro,Brazil,20231-050[60]Grupo Oncoclínicas Botafogo,Rio de Janeiro,Brazil,22250-905[61]Icesp - Instituto Do Câncer Do Estado de São Paulo,São Paulo,Brazil,01246-000[62]Núcleo de Pesquisa Clínica da Rede São Camilo,São Paulo,Brazil,04014-002[63]Instituto de Assist├ncia M├dica ao Servidor P,São Paulo,Brazil,04039-901[64]Hamilton Health Sciences-Juravinski Cancer Centre,Hamilton,Ontario,Canada,L8V5C2[65]CIUSSS- saguenay-Lac-Saint-Jean,Chicoutimi,Quebec,Canada,G7H 5H6[66]Wannan Medical College Yijishan Hospital,Wuhu,Anhui,China,241001[67]Cancer Hospital Chinese Academy of Medical Science,Beijing,Beijing,China,100021[68]Beijing Cancer hospital,Beijing,Beijing,China,100142[69]The First Affiliated Hospital of the Third Military Medical University,Shapingba,Chongqing,China,400038[70]Fujian Provincial Cancer Hospital,Fuzhou,Fujian,China,350014[71]The First Affiliated Hospital, Sun Yat-sen University,Guangzhou,Guangdong,China[72]Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong,China,524004[73]Liuzhou People's Hospital,Liuzhou,Guangxi,China,545006[74]Harbin Medical University Cancer Hospital,Harbin,Heilongjiang,China,150081[75]Wuhan Union Hospital,Wuhan,Hubei,China,430022[76]Tongji Hospital Tongji Medical,Science & Technology,Wuhan,Hubei,China,430030[77]Xiangya Hospital Central South University,Changsha,Hunan,China,410008[78]Hunan Cancer Hospital,Changsha,Hunan,China,410013[79]Hunan Cancer Hospital,Changsha,Hunan,China,410013[80]ZhuZhou Central Hospital,Zhuzhou,Hunan,China,412007
研究目的：
The purpose of this study is to assess if adding LY3537982 in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change in a gene called KRAS G12C. Study participation, including follow-up, could last up to 3 years, depending on how you and your lung cancer are doing.
