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Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa

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研究单位: [1]Guangzhou Medical University [2]Dongguan Maternal and Child Health Care Hospital [3]Foshan Women and Children Hospital [4]BoAi Hospital of Zhongshan [5]Women and Children's Hospital of Chongqing Medical University [6]Tianjin Central Hospital of Gynecology Obstetrics [7]Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan [8]Urumqi Maternal and Child Health Care Hospital [9]Zhuhai Women and Children's Hospital [10]The First Affiliated Hospital of Zhengzhou University [11]Hunan Provincial Maternal and Child Health Care Hospital [12]Dalian women and children's medical group [13]Nanfang Hospital, Southern Medical University [14]Huadu District People's Hospital of Guangzhou [15]Northwest Women's and Children's Hospital, Xi'an, Shaanxi [16]First Affiliated Hospital, Sun Yat-Sen University [17]Shenzhen Maternity & Child Healthcare Hospital [18]Shenzhen Baoan Women's and Children's Hospital [19]Dongguan People's Hospital [20]First Affiliated Hospital of Xinjiang Medical University [21]Tongji Hospital [22]Peking Union Medical College [23]Peking University First Hospital [24]Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China,510150 [25]Peking Union Medical College,Beijing,China [26]Peking University First Hospital,Beijing,China [27]Women and Children's Hospital of Chongqing Medical University,Chongqing,China [28]Dalian Women and Children's Medical Group,Dalian,China [29]Dongguan Maternal and Child Health Care Hospital,Dongguan,China [30]The Tenth Affiliated Hospital of Southern Medical University [31]Dongguan People's Hospital,Dongguan,China [32]Foshan Women and Children Hospital,Foshan,China [33]Boai Hospital of Zhongshan,Guangzhou,China [34]Huadu District People's Hospital of Guangzhou,Guangzhou,China [35]Nanfang Hospital, Southern Medical University, Guangzhou,Guangzhou,China [36]The first Affiliated Hospital, Sun Yat-sen University,Guangzhou,China [37]Zhuhai Women and Children's Hospital,Guangzhou,China [38]Obstetrics Department, the Maternal and Child Health Hospital of Hunan Province,Hunan,China [39]Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University,Jinan,China [40]Shenzhen Baoan Women's and Children's Hospital,Shenzhen,China [41]Shenzhen Maternal & Child Healthcare Hospital Affiliated Southern Medical University,Shenzhen,China [42]Tianjin Central Hospital of Gynecology Obsterics,Tianjin,China [43]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China [44]Northwest Women's and Children's Hospital,Xi'an,China [45]First Affiliated Hospital of Xinjiang Medical University,Xinjiang,China [46]Urumqi Maternal and Child Health Care Hospital,Xinjiang,China [47]The First Affiliated Hospital of Zhengzhou University,Zhengzhou,China

研究目的:
Many RCT(randomized controlled trial) studies reported that tranexamic acid reduced blood loss in women who had elective cesareans. However, most of these elective cesareans are without high-risk factors of postpartum hemorrhage, such as placenta previa. The prophylactic use of tranexamic acid in the placenta previa is not clear. studies had poor quality and lacked adequate power to assess severe adverse events.

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