Efficacy and Safety of Sitravatinib Plus Tislelizumab or Placebo Plus Tislelizumab Versus Placebo as Adjuvant Treatment in Participants With Hepatocellular Carcinoma
研究单位：[1]BeiGene[2],Korea, Republic of,58128[3],Dusit,Bangkok,Thailand,10300[4],Chiang Mai,Muang,Thailand,50200[5]The First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui,China,233004[6]Beijing Cancer Hospital,Beijing,Beijing,China,100142[7]Peking Union Medical College Hospital - Oncology,Beijing,Beijing,China,100730[8]Cancer Hospital Chinese Academy of Medical Sciences City: Beijing,Beijing,Beijing,China[9]Peking University Third Hospital,Beijing,Beijing,China[10]Daping Hospital, Third Military Medical University,Chongqing,Chongqing,China,400042[11]Fujian Cancer Hospital,Fuzhou,Fujian,China,350014[12]Zhongshan Hospital,Fudan University (Xiamen Branch）,Xiamen,Fujian,China,361006[13]Mengchao Hepatobiliary Hospital of Fujian Medical University,Gulou,Fuzhou,China[14]The First Hospital of Lanzhou University,Lanzhou,Gansu,China,73000[15]Zhujiang Hospital of Southern Medical University,Guangzhou,Guangdong,China,510000[16]Sun Yat-Sen University Cancer Center (Huangpu Campus),Guangzhou,Guangdong,China,510060[17]Guangdong Provincial People's Hospital,Guangzhou,Guangdong,China,510080[18]Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University,Guangzhou,Guangdong,China,510120[19]Nanfang Hospital of Southern Medical University,Guangzhou,Guangdong,China,510515[20]Sun yat-sen memorial hospital, sun yat-sen university (south),Guanzhou,Guangdong,China,510275[21]The First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi,China,530021[22]Guizhou Cancer Hospital,Guiyang,Guizhou,China,550000[23]Hainan General Hospital - Oncology,Haikou,Hainan,China[24]Second Affiliated Hospital of Zhejiang University School of Medicine,Zhejiang,Hangzhou,China,310009[25]Harbin Medical University Cancer Hospital - Oncology,Haerbin,Heilongjiang,China,150081[26]Hubei Cancer Hospital - Oncology,Wuhan,Hubei,China,400037[27]Union Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan,Hubei,China[28]Hunan Cancer Hospital,Changsha,Hunan,China,410013[29]The First People's Hospital of Changzhou - Oncology,Changzhou,Jiangsu,China,213003[30]Nantong Tumor Hospital,Nantong,Jiangsu,China,226000[31]Affiliated hospital of Nantong university,Nantong,Jiangsu,China,226001[32]Northern Jiangsu people's hospital - Oncology,Yangzhou,Jiangsu,China,225001[33]The Second Affiliated Hospital of Nanchang University,Nanchang,Jiangxi,China,330006[34]Jiangxi Province Cancer Hospital,Nanchang,Jiangxi,China,330039[35]The First Hospital of China Medical University,Shenyang,Liaoning,China,110001[36]Liaoning Cancer Hospital & Institute - Medical Oncology - Oncology,Shenyang,Liaoning,China,110017[37]Shengjing Hospital of China Medical University,Shenyang,Liaoning,China,110022[38]The Second Affiliated Hospital of Fujian Medical University,Fujian,Quanzhou,China,362001[39]Shandong Cancer Hospital - oncology - Oncology,Jinan,Shandong,China[40]The Affiliated Hospital of Qingdao University Branch South,Qingdao,Shandong,China,266000[41]Affiliated Zhongshan Hospital of Fudan University,Shanghai,Shanghai,China,200032[42]Shanxi Provincial Cancer Hospital,Taiyuan,Shanxi,China,030013[43]Sichuan Cancer Hospital & Institute,Chengdu,Sichuan,China,610041[44]West China Hospital, Sichuan University,Chengdu,Sichuan,China,610041[45]Tianjin Medical University Cancer Institute & Hospital,Tianjin,Tianjin,China[46]Affiliated Cancer Hospital of Xinjiang Medical University,Ürümqi,Xinjiang,China[47]The First Affiliated Hospital of Xinjiang Medical University,Ürümqi,Xinjiang,China[48]Yunnan Cancer Hospital - Oncology,Kunming,Yunnan,China,650100[49]Yunnan Cancer Hospital, &The Third Affiliated Hospital of Kunming Medical University&Yunnan Cancer Center &Yunnan Cancer Center,Kunming,Yunnan,China,650118[50]The First Affiliated Hospital, Zhejiang University School of Medicine,Hangzhou,Zhejiang,China[51]Taizhou Hospital of Zhejiang Province,Taizhou,Zhejiang,China,317000[52]The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China[53]The First Affiliated Hospital of Chongqing Medical University,Chongqing,China[54]Zhongshan Hospital Xiamen University,Fujian,China[55]Anhui Provincial Hospital - Oncology,Hefei,China,230001[56]Linyi Cancer Hospital,Shandong,China[57]Tongji Hospital of Tongji Medical College Huazhong University of Science Technology,Wuhan,China,Hubei[58]The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,China,710061[59]The Catholic University of Korea, Bucheon St. Mary's Hospital,Gyeonggi-do,Bucheon-si,Korea, Republic of,14647[60]Kyungpook National University Hospital,Daegu,Chungcheongnam-do,Korea, Republic of[61]National Cancer Center (NCC),Goyang-si,Gyeonggi-do,Korea, Republic of,10408[62]Samsung Medical Center - Hematology-Oncology,Seoul,Seoul Teugbyeolsi [Seoul-T'ukp,Korea, Republic of,06351[63]Korea University Guro Hospital - Hematology-Oncology,Seoul,Seoul Teugbyeolsi [Seoul-T'ukp,Korea, Republic of,08308[64]Pusan National University Hospital,Busan,Korea, Republic of,49241[65]Ajou University Hospital,Gyeonggi-do,Korea, Republic of,16499[66]Seoul National University Bundang Hospital,Seongnam-si,Korea, Republic of,13620[67]Seoul National University Hospital,Seoul,Korea, Republic of,03080[68]Severance Hospital Yonsei University Health System,Seoul,Korea, Republic of,03722[69]The Catholic University of Korea, Seoul St. Mary's Hospital,Seoul,Korea, Republic of,06591[70]Asan Medical Center - Oncology,Seoul,Korea, Republic of,5505[71]Kaohsiung Chang Gung Memorial Hospital,Kaohsiung,Taiwan,83301[72]China Medical University Hospital - Oncology - Taichung,Taichung,Taiwan,40447[73]Taichung Veterans General Hospital,Taichung,Taiwan[74]Chi Mei Medical Center - YongKang,Tainan,Taiwan[75]National Taiwan University Hospital (NTUH),Taipei,Taiwan,100225[76]Taipei Veterans General Hospital,Taipei,Taiwan,11217[77]Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital,Taipei,Taiwan[78]Mackay Memorial Hospital,Taipei,Taiwan[79]Sunpasitthiprasong Hospital,Ubon Ratchathani,Muang,Thailand,34000[80]King Chulalongkorn Memorial Hospital (Chulalongkorn University),Bangkok,Panthumwan,Thailand,10330[81]Siriraj Hospital,Bangkok,Thailand,10700[82]Songklanagarind Hospital (Prince of Songkhla University),Hat Yai,Thailand,90110[83]Srinagarind Hospital (Khon Kaen University),Mueang Nonthaburi,Thailand,40002
The purpose of this study is to compare the efficacy and safety of sitravatinib plus tislelizumab or placebo plus tislelizumab versus placebo. The study will also compare the recurrence-free survival (RFS) in participants with hepatocellular carcinoma (HCC) who are at high risk of recurrence after surgical resection.
