A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma
研究单位：[1]Janssen Research & Development, LLC[2]The University of Arizona Cancer Center,Tucson,Arizona,United States,85719[3]University of Arkansas for Medical Sciences,Little Rock,Arkansas,United States,72205[4]City of Hope,Duarte,California,United States,91010[5]University of California San Francisco,San Francisco,California,United States,94143[6]Norwalk Hospital-oncology,Norwalk,Connecticut,United States,06850[7]MedStar Georgetown University Hospital,Washington,District of Columbia,United States,20007[8]University of Miami Health System,Miami,Florida,United States,33136[9]Grady Memorial Hospital,Atlanta,Georgia,United States,30303[10]University Of Illinois Medical Center,Chicago,Illinois,United States,60612[11]University of Iowa Hospital & Clinics,Iowa City,Iowa,United States,52242[12]University of Kansas,Westwood,Kansas,United States,66205[13]Tulane University Hospital & Clinics,New Orleans,Louisiana,United States,70112[14]Oschner Health System,New Orleans,Louisiana,United States,70121-2429[15]University Of Maryland Medical Center,Baltimore,Maryland,United States,21201[16]Johns Hopkins University,Baltimore,Maryland,United States,21205[17]Massachusetts General,Boston,Massachusetts,United States,02114[18]Boston University Medical Center,Boston,Massachusetts,United States,02118[19]University of Massachusetts Medical School,Worcester,Massachusetts,United States,01655[20]University of Michigan Health System,Ann Arbor,Michigan,United States,48109[21]University Of Minnesota,Minneapolis,Minnesota,United States,55455[22]University of Mississippi Medical Center,Jackson,Mississippi,United States,39216[23]Washington University School of Medicine,Saint Louis,Missouri,United States,63110-1032[24]Rutgers Cancer Institute of New Jersey,New Brunswick,New Jersey,United States,08903[25]Roswell Park Cancer Institute,Buffalo,New York,United States,14263[26]NYU Langone Health,New York,New York,United States,10016[27]University of North Carolina,Chapel Hill,North Carolina,United States,27599[28]Levine Cancer Institute, Carolinas HealthCare System,Charlotte,North Carolina,United States,28204[29]Novant Health,Charlotte,North Carolina,United States,28204[30]Wake Forest Baptist Medical Center,Winston-Salem,North Carolina,United States,27157[31]University Hospitals Cleveland Medical Center,Cleveland,Ohio,United States,44106[32]The Ohio State University Wexner Medical Center - James Cancer Hospital,Columbus,Ohio,United States,43210[33]OhioHealth,Columbus,Ohio,United States,43214[34]Thomas Jefferson University,Philadelphia,Pennsylvania,United States,19107-4215[35]Baptist Cancer Center,Memphis,Tennessee,United States,38120[36]University of Texas Southwestern Medical Center,Dallas,Texas,United States,75390[37]Houston Methodist Hospital,Houston,Texas,United States,77030[38]MD Anderson Cancer Center,Houston,Texas,United States,77030[39]Huntsman Cancer Institute,Salt Lake City,Utah,United States,84112[40]Virginia Commonwealth University - Massey Cancer Center,Richmond,Virginia,United States,23219[41]Seattle Cancer Care Alliance,Seattle,Washington,United States,98109[42]University of Wisconsin-Madison,Madison,Wisconsin,United States,53792-4108[43]UZ Brussel,Brussel,Belgium,1090[44]UZA,Edegem,Belgium,2650[45]Virga Jessa Ziekenhuis,Hasselt,Belgium,3500[46]CHC MontLegia,Liège,Belgium,4000[47]Clinique Saint Pierre,Ottignies,Belgium,1340[48]UCL Mont Godinne,Yvoir,Belgium,5530[49]Hospitais Integradaos da Gavea S/A - DF Star,Brasilia,Brazil,70390-140[50]Fundação Universidade de Caxias do Sul,Caxias do Sul,Brazil,95070 560[51]Liga Paranaense de Combate ao Cancer,Curitiba,Brazil,81520-060[52]Centro de Pesquisa e Ensino em Oncologia de Santa Catarina - CEPEN,Florianopolis,Brazil,88034-000[53]Liga Norte Riograndense Contra O Cancer,Natal,Brazil,59062-000[54]Irmandade Santa Casa de Misericordia de Porto Alegre,Porto Alegre,Brazil,90050-170[55]Hospital das Clínicas da Faculdade de Medicina de RPUSP - HCRP,Ribeirão Preto,Brazil,14051-140[56]Oncoclínicas Rio de Janeiro S.A.,Rio de Janeiro,Brazil,22250-905[57]Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI),Rio de Janeiro,Brazil,22775-001[58]Hospital Sao Rafael,Salvador,Brazil,41253-190[59]Instituto de Ensino e Pesquisa São Lucas,Sao Paulo,Brazil,01236-030[60]Fundação Antônio Prudente - A.C. Camargo Cancer Center,Sao Paulo,Brazil,01509900[61]Sociedade Beneficente de Senhoras - Hospital Sírio Libanês,São Paulo,Brazil,01308-901[62]Hospital Paulistano,São Paulo,Brazil,01321-001[63]Clinica Sao Germano,São Paulo,Brazil,01455-010[64]Instituto D'Or de Pesquisa e Ensino (IDOR),São Paulo,Brazil,4501000[65]Peking Union Medical College Hospital,Beijing,China,100006[66]Beijing Chaoyang Hospital,Beijing,China,100020[67]Peking University First Hospital,Beijing,China,100034[68]The First Hospital of Jilin University,Changchun,China,130021[69]The second Xiangya Hospital of Central South University,ChangSha,China,410000[70]Sichuan Academy of Medical Science Sichuan Provincial People's Hospital,Chengdu,China,610072[71]Xinqiao Hospital. Army Medical University,Chongqing,China,400037[72]Fujian Medical University Union Hospital,Fuzhou,China,350001[73]Sun Yat-Sen University Cancer Center,Guangzhou,China,510060[74]Guangdong Provincial People's Hospital,Guangzhou,China,510080[75]The First Affiliated Hospital, Zhejiang University College of Medicine,Hangzhou,China,310003[76]Nanjing Drum Tower Hospital,Nanjing,China,210008[77]Tongji Hospital of Tongji University,Shanghai,China,200065[78]Shanghai Fourth People'[79]s Hospital,Shanghai,China,200434[80]Peking University Shenzhen Hospital,Shenzhen,China,518036[81]First Affiliated Hospital, SooChow University,Su Zhou,China,215006[82]Tianjin cancer hospital,Tianjin,China,300060[83]Institute of Hematology & Blood Disease Hospital Chinese Academy of Medical Science,Tianjin,China,300320[84]Tongji Hospital, Tongji Medical College of HUST,Wuhan,China,430030[85]The First Affiliated Hospital of Xi'an Jiaotong University,Xi' An,China,710061[86]Henan Cancer Hospital,Zhengzhou,China,450008[87]Fakultni nemocnice Brno,Brno,Czechia,625 00[88]Fakultni nemocnice Hradec Kralove,Hradec Kralove,Czechia,500 05[89]Fakultní nemocnice Olomouc,Olomouc,Czechia,779 00[90]Fakultni nemocnice Ostrava,Ostrava,Czechia,70852[91]Fakultni nemocnice Kralovske Vinohrady,Praha 10,Czechia,100 34[92]Vseobecna fakultni nemocnice v Praze - I. interni klinika - klinika hematologie,Praha 2,Czechia,128 08[93]APHP - Hopital Henri Mondor,Creteil,France,94010[94]CHU Dijon,Dijon,France,21000[95]Centre Leon Bérard,Lyon,France,69008[96]CHU de Montpellier - Hopital Saint-Eloi,Montpellier Cedex 5,France,34295[97]CHU de Nantes hôtel-Dieu,Nantes,France,44093[98]CHU HOPITAL DE L'ARCHET - Hematology,Nice N/a,France,06202[99]CHU Hopital Saint Antoine,Paris Cedex 12,France,75571[100]CHRU - Hôpital du Haut Lévêque - Centre François Magendie,Pessac,France,33604[101]Chu Rennes - Hopital Pontchaillou,Rennes,France,35000[102]Institut Universitaire du cancer de Toulouse-Oncopole,TOULOUSE Cedex 9,France,31059[103]Charite Campus Benjamin Franklin,Berlin,Germany,12203[104]Universitatsklinikum Essen,Essen,Germany,D-45147[105]Asklepios Klinik Altona,Hamburg,Germany,22763[106]Universitaetsklinikum Heidelberg,Heidelberg,Germany,69120[107]Universitaetsklinikum Koeln,Koeln,Germany,50937[108]Universitatsklinikum Leipzig,Leipzig,Germany,04103[109]Universitätsmedizin der Johannes Gutenberg Universität,Mainz,Germany,55131[110]Klinikum rechts der Isar der TU Munchen,Munchen,Germany,81675[111]Universitaetsklinikum Wuerzburg,Wuerzburg,Germany,97080[112]Alexandra General Hospital of Athens,Athens Attica,Greece,115 28[113]University of Athens - Evaggelismos Hospital (Evangelismos Hospital),Athens,Greece,106 76[114]'G. Papanikolaou' Hospital of Thessaloniki,Thessalonikis,Greece,570 10[115]Anticancer Hospital of Thessaloniki 'Theageneio',Thessaloniki,Greece,546 39[116]Bnai Zion Medical Center,Haifa,Israel,31048[117]Rambam Medical Center,Haifa,Israel,31096[118]Carmel Medical Center,Haifa,Israel,34362[119]Shaare Zedek Medical Center,Jerusalem,Israel,9103102[120]Hadassah Medical Center,Jerusalem,Israel,91120[121]Galilee Medical Center,Nahariya,Israel,22100[122]Beilinson medical center,Petah Tikva,Israel,49100[123]Sheba Medical Center,Ramat Gan,Israel,52621[124]Ziv Medical Center,Safed,Israel,13100[125]Sourasky (Ichilov) Medical Center,Tel Aviv,Israel,6423906[126]A.O. Universitaria Ospedali Riuniti di Ancona,Ancona,Italy,60126[127]Policlinico di Bari,Bari,Italy,70124[128]Azienda Ospedaliera Policlinico S. Orsola-Malpighi,Bologna,Italy,40138[129]Azienda Ospedaliera Spedali Civili di Brescia,Brescia,Italy,25123[130]PO G.Rodolico, AOU Policlinico-Vittorio Emanuele Catania,Catania,Italy,95123[131]Fondazione IRCCS Istituto Nazionale dei Tumori,Milano,Italy,20133[132]ASST Grande Ospedale Metropolitano Niguarda,Milano,Italy,20162[133]Azienda Ospedaliera Universitaria di Padova,Padova,Italy,35128[134]Ospedale Villa Sofia-Cervello,Palermo,Italy,90146[135]Fondazione IRCCS Policlinico San Matteo,Pavia,Italy,27100[136]Arcispedale Santa Maria Nuova - IRCCS,Reggio Emilia,Italy,42123[137]Presidio Ospedaliero Santo Spirito in Sassia,Roma,Italy,00193[138]IRCCS Ospedale Casa Sollievo della Sofferenza,San Giovanni Rotondo,Italy,71013[139]A.O.U. Città della Salute e della Scienza,Torino,Italy,10126[140]Chiba Cancer Center,Chiba,Japan,260-8717[141]Ogaki Municipal Hospital,Gifu,Japan,503-8502[142]Gunma University Hospital,Gunma,Japan,371-0034[143]Kansai Medical University Hospital,Hirakata,Japan,573-1191[144]Hyogo Medical University Hospital,Hyôgo,Japan,663-8501[145]Shonan Kamakura General Hospital,Kamakura-shi,Japan,247-8533[146]National Cancer Center Hospital East,Kashiwa,Japan,277-8577[147]Dokkyo Medical University Saitama Medical Center,Koshigaya,Japan,343-8555[148]Kumamoto University Hospital,Kumamoto,Japan,860-8556[149]Kyoto Kuramaguchi Medical Center,Kyoto,Japan,603-8151[150]National Hospital Organization Matsumoto Medical Center,Matsumoto,Japan,399-8701[151]Niigata Cancer Center Hospital,Niigata,Japan,951-8566[152]Hokkaido University Hospital,Sapporo-shi,Japan,060-8648[153]Tohoku University Hospital,Sendai,Japan,980-8574[154]Iwate Medical University Hospital,Shiwa-gun,Japan,028-3695[155]Osaka University Hospital,Suita-shi,Japan,565-0871[156]The Cancer Institute Hospital of JFCR,Tokyo,Japan,135-8550[157]Dong-A University Hospital,Busan,Korea, Republic of,602-812[158]National Cancer Center,Gyeonggi-do,Korea, Republic of,10408[159]Gachon University Gil Medical Center,Incheon,Korea, Republic of,21565[160]Chonnam National University Hwasun Hospital,Jeollanam-do,Korea, Republic of,58128[161]Jeonbuk National University Hospital,Jeonju-si,Korea, Republic of,54907[162]Seoul National University Hospital,Seoul,Korea, Republic of,03080[163]Severance Hospital, Yonsei University Health System,Seoul,Korea, Republic of,03722[164]Asan Medical Center,Seoul,Korea, Republic of,05505[165]Samsung Medical Center,Seoul,Korea, Republic of,06351[166]The Catholic University of Korea Seoul St. Mary's Hospital,Seoul,Korea, Republic of,06591[167]Haga zkh,Den-Haag,Netherlands,2545 CH[168]Albert Schweitzer ziekenhuis-lokatie Dordwijk,Dordrecht,Netherlands,3318 AT[169]Maxima Medisch Centrum,Eindhoven,Netherlands,5631 BM[170]Maastricht University Medical Centre,Maastricht,Netherlands,6229 HX[171]Erasmus MC,Rotterdam,Netherlands,3015 CN[172]Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza,Brzozow,Poland,36-200[173]Uniwersyteckie Centrum Kliniczne,Gdansk,Poland,80-214[174]Pratia Onkologia Katowice,Katowice,Poland,40-519[175]Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach,Kielce,Poland,25-734[176]Szpital Uniwersytecki w Krakowie,Krakow,Poland,31-501[177]Centrum Onkologii Ziemi Lubelskiej im. Św. Jana z Dukli,Lublin,Poland,20090[178]SP ZOZ MSWiA z Warmińsko-Mazurskim Centrum Onkologii w Olsztynie, Oddział Hematologii,Olsztyn,Poland,10-228[179]Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy,Warszawa,Poland,02-781[180]Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu,Wroclaw,Poland,50-367[181]Hosp. Univ. Germans Trias I Pujol,Badalona,Spain,08916[182]Hosp. Univ. Vall D Hebron,Barcelona,Spain,08035[183]Hosp. Clinic I Provincial de Barcelona,Barcelona,Spain,08036[184]Hosp. de la Santa Creu I Sant Pau,Barcelona,Spain,08041[185]Hosp. Univ. Virgen de La Arrixaca,El Palmar, Murcia,Spain,30120[186]Hosp. de Jerez de La Frontera,Jerez de la Frontera,Spain,11407[187]Hosp. de Leon,Leon,Spain,24071[188]Hosp. Univ. de La Princesa,Madrid,Spain,28006[189]Hosp. Univ. 12 De Octubre,Madrid,Spain,28041[190]Hosp. Virgen de La Victoria,Malaga,Spain,29010[191]Hosp. Clinico Univ. de Salamanca,Salamanca,Spain,37007[192]Hosp. Univ. de Canarias,San Cristóbal de La Laguna,Spain,38320[193]Hosp. Univ. Dr. Peset,Valencia,Spain,46017[194]Kaohsiung Medical University Chung-Ho Memorial Hospital,Kaohsiung,Taiwan,80756[195]Kaohsiung Chang Gung Memorial Hospital,Kaohsiung,Taiwan,83301[196]China Medical University Hospital,Taichung City,Taiwan,40447[197]National Cheng Kung University Hospital,Tainan,Taiwan,704[198]National Taiwan University Hospital,Taipei,Taiwan,10048[199]Taipei Veterans General Hospital,Taipei,Taiwan,112[200]Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Hematology Unit,Ankara,Turkey,06200[201]Ankara University Medical Faculty,Ankara,Turkey,06590[202]Medipol Mega University Hospital,Istabul,Turkey,34214[203]Istanbul University Istanbul Medical Faculty,Istanbul,Turkey,34093[204]Istanbul University Cerrahpasa Medical Faculty,Istanbul,Turkey,34098[205]Dokuz Eylul University Medical Faculty,Izmir,Turkey,35330[206]On Dokuz Mayıs University Medical Faculty,Samsun,Turkey,55139[207]Blackpool Victoria Hospital,Blackpool,United Kingdom,FY3 8NR[208]Ninewells Hospital & Medical School,Dundee,United Kingdom,DD1 9SY[209]Newcastle Freeman Hospital,Newcastle Upon Tyne,United Kingdom,NE7 7DN[210]Nottingham City Hospital,Nottingham,United Kingdom,NG5 1PB[211]University Hospitals Plymouth NHS Trust,Plymouth,United Kingdom,PL6 8DH[212]Royal Hallamshire Hospital,Sheffield,United Kingdom,S10 2JF[213]Royal Marsden Hospital,Sutton,United Kingdom,SM2 5PT[214]New Cross Hospital,Wolverhampton,United Kingdom,WV10 0QP
研究目的：
The purpose of the study is to compare the efficacy of talquetamab subcutaneous(ly) (SC) in combination with daratumumab SC and pomalidomide (Tal-DP) and talquetamab SC in combination with daratumumab SC (Tal-D), respectively, with daratumumab in combination with pomalidomide and dexamethasone (DPd).
