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Chronic Obstructive Pulmonary Disease With Asthma-Like Features in the General Population in China.

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收录情况： ◇ 预警期刊

作者：
Huang Kewu[1,2] * ; Chung Kian Fan[3] ; Yang Ting[4,5,6,7] ; Xu Jianying[8] ; Yang Lan[9] ; Zhao Jianping[10] ; Zhang Xiangyan[11] ; Bai Chunxue[12] ; Kang Jian[13] ; Ran Pixin[14] ; Shen Huahao[15] ; Wen Fuqiang[16] ; Chen Yahong[17] ; Sun Tieying[18,19] ; Shan Guangliang[20] ; Lin Yingxiang[1,2] ; Xu Guodong[21] ; Wu Sinan[4,6,21] ; Wang Ying[1,2] ; Gu Xiaoying[4,5,7,21] ; Wang Ruiying[8] ; Shi Zhihong[9] ; Xu Yongjian[10] ; Ye Xianwei[11] ; Song Yuanlin[12] ; Wang Qiuyue[13] ; Zhou Yumin[14] ; Li Wen[15] ; Ding Liren[15] ; Wan Chun[16] ; Yao Wanzhen[17] ; Guo Yanfei[18,19] ; Xiao Fei[19] ; Lu Yong[1,2] ; Peng Xiaoxia[22] ; Xiao Dan[4,5,7,23,24] ; Bu Xiaoning[1,2] ; Zhang Hong[1,2] ; Zhang Xiaolei[4,5,6,7] ; An Li[1,2] ; Zhang Shu[1,2] ; Cao Zhixin[1,2] ; Zhan Qingyuan[4,5,6,7] ; Yang Yuanhua[1,2] ; Liang Lirong[2,25] ; Wang Wenjun[1,2] ; Dai Huaping[4,5,6] ; Cao Bin[4,5,6] ; He Jiang[26] ; Wang Chen[4,5,6,7,23,24,27,28] ;
单位： [1]Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China. [2]Beijing Institute of Respiratory Medicine, Beijing, China. [3]National Heart & Lung Institute, Imperial College London & Royal Brompton & Harefield NHS Trust, London, United Kingdom. [4]National Center for Respiratory Medicine, Beijing, China. [5]National Clinical Research Center for Respiratory Diseases, Beijing, China. [6]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. [7]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China. [8]Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Taiyuan, China. [9]Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. [10]Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [11]Department of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China. [12]Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. [13]Department of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China. [14]State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. [15]Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China. [16]State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China. [17]Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China. [18]Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China. [19]National Center of Gerontology, Beijing Hospital, Beijing, China. [20]Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences School of Basic Medicine, Peking Union Medical College, Beijing, China. [21]Department of Clinical Research and Data Management, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. [22]Center for Clinical Epidemiology and Evidence-Based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. [23]Tobacco Medicine and Tobacco Cessation Center, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. [24]WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China. [25]Department of Epidemiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. [26]Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States. [27]Department of Respiratory Medicine, Capital Medical University, Beijing, China. [28]Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出处：
DOI： 10.3389/fmed.2022.876240
ISSN：

关键词： asthma bronchodilator response chronic obstructive pulmonary disease general population wheeze

摘要：
Patients with features of both asthma and chronic obstructive pulmonary disease (COPD) are seen commonly in the clinic but less is known in the general population. We investigated the prevalence and the heterogeneity of COPD with concomitant features of asthma in Chinese adult population.COPD was defined as post-bronchodilator ratio of forced expiratory volume in 1s (FEV1) to forced vital capacity of less than the lower limits of normal. COPD with concomitant features of asthma was defined as either COPD with asthma diagnosed by self-reported physician-diagnosis or by presence of current wheeze, or as COPD with high bronchodilator response (HBR) defined as an increase in FEV1 >15% and >400 ml after bronchodilator.COPD with concomitant features of asthma was found in 1.62% (95% CI 1.31-2.00) of adults (≥20 years) or in 15.2% (95% CI 13.0-17.7) of COPD patients. Compared with COPD with HBR, COPD with asthma diagnosis or wheeze were older (61.8 ± 1.1 years vs. 47.4 ± 2.8 years, P < 0.001), and with a lower post-bronchodilator FEV1%pred (68.2 ± 2.3 vs. 96.6 ± 3.4, P < 0.001). Age, smoking status, biomass use and allergic rhinitis were associated with increasing prevalence of COPD with asthma diagnosis or wheeze, and had greater impaired health status, more comorbidities and more acute exacerbations in the preceding 12 months.COPD with concomitant features of asthma is common in people with COPD and those with COPD with asthma diagnosis or wheeze experience worse clinical severity than COPD with HBR. These findings will help toward the definition of the asthma-COPD overlap condition.Copyright © 2022 Huang, Chung, Yang, Xu, Yang, Zhao, Zhang, Bai, Kang, Ran, Shen, Wen, Chen, Sun, Shan, Lin, Xu, Wu, Wang, Gu, Wang, Shi, Xu, Ye, Song, Wang, Zhou, Li, Ding, Wan, Yao, Guo, Xiao, Lu, Peng, Xiao, Bu, Zhang, Zhang, An, Zhang, Cao, Zhan, Yang, Liang, Wang, Dai, Cao, He and Wang.

基金：
CW was supported by the National Key R&D Program grant 2018YFC1315102 and 2016YFC0901100 from Ministry of Science and Technology of China and the Special Research Foundation for Public welfare of Health grant 201002008 from Ministry of Health of China. KH was partly supported by National Key R&D Program of China grant 2016YFC0901102 from Ministry of Science and Technology of China, the National Natural Science Foundation of China grant 81870032 and the ‘Summit’ talent training program grant DFL20190301 from Beijing Hospital Authority.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 医学
小类 | 2 区 医学：内科
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 医学：内科
第一作者：
第一作者单位： [1]Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China. [2]Beijing Institute of Respiratory Medicine, Beijing, China.
通讯作者：
通讯机构： [4]National Center for Respiratory Medicine, Beijing, China. [5]National Clinical Research Center for Respiratory Diseases, Beijing, China. [6]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. [7]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China. [23]Tobacco Medicine and Tobacco Cessation Center, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. [24]WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China. [27]Department of Respiratory Medicine, Capital Medical University, Beijing, China. [28]Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
推荐引用方式(GB/T 7714)：
Huang Kewu,Chung Kian Fan,Yang Ting,et al.Chronic Obstructive Pulmonary Disease With Asthma-Like Features in the General Population in China.[J].Frontiers in medicine.2022,9:876240.doi:10.3389/fmed.2022.876240.
APA：
Huang Kewu,Chung Kian Fan,Yang Ting,Xu Jianying,Yang Lan...&Wang Chen.(2022).Chronic Obstructive Pulmonary Disease With Asthma-Like Features in the General Population in China..Frontiers in medicine,9,
MLA：
Huang Kewu,et al."Chronic Obstructive Pulmonary Disease With Asthma-Like Features in the General Population in China.".Frontiers in medicine 9.(2022):876240

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