Objective: The aim of this study was to elucidate the association of COVID-19 prognosis with the indexes of inflammation and coagulation. Methods: The clinical data of 103 cases of COVID-19 were retrospectively analyzed. COX regression models and 95% confidence intervals (CIs) were applied to estimate the COVID-19 prognosis. Results: The results showed that C-reactive protein (HR=1.007, p<0.001), procalcitonin (HR=1.013, p=0.006), prothrombin time (HR=1.190, p<0.001), Fibrinogen (HR=0.784, p=0.002) and D-dimer (HR=1.078, p<0.001) is associated with an increased risk of COVID-19 death. Among the inflammation indicators, the maximum area under the ROC curve of NLR is 0.87. In the coagulation index, the maximum area under the ROC curve of PT is 0.84. For the combined indicators of inflammation and coagulation, the area under the ROC curve is 0.89. Conclusions: In conclusion, we found that the length of PT at admission and the level of fibrinogen and D-dimer were related to the risk of COVID-19 death. It may be considered to jointly predict the risk of death of COVID-19 with inflammation and coagulation indicators.