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Design and synthesis of copper nanoparticles for the treatment of human esophageal cancer: introducing a novel chemotherapeutic supplement

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单位： [1]Shanxi Canc Hosp, Dept Thorac Surg, Taiyuan, Peoples R China [2]Shanxi Canc Hosp, Dept Gastroenterol, Taiyuan, Peoples R China [3]Shanxi Med Univ, Dept Endocrinol & Metab, Shanxi Bethune Hosp, Shanxi Acad Med Sci,Tongji Shanxi Hosp,Hosp 3, Taiyuan, Peoples R China [4]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Endocrinol & Metab, Wuhan, Peoples R China

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关键词： Cu nanoparticles green synthesis esophageal cancer chemotherapeutic supplement

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In this study, copper nanoparticles (Cu NPs) were synthesized in an eco-friendly pathway applying Mentha piperita extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared nanoparticles were determined using several advanced techniques like FE-SEM, EDX, and UV-Vis studies. The as synthesized Cu NPs was explored in the antioxidant and anti-human esophageal cancer tests. The in vitro cytotoxic and anti-esophageal cancer effects of biologically synthesized Cu NPs against human esophageal squamous cell carcinoma (KYSE-270), human caucasian esophageal carcinoma (OE33), and adenocarcinoma of the gastroesophageal junction (ESO26) cancer cell lines were assessed. The anti-esophageal cancer properties of the Cu NPs could significantly remove KYSE-270, OE33, and ESO26 cancer cell lines in a time and concentration-dependent manner by MTT assay. The IC50 of the Cu NPs were 241, 278, and 240 mu g/mL against KYSE-270, OE33, and ESO26 cancer cell lines. The antioxidant activity of Cu NPs was determined by DPPH method. The Cu NPs showed the high antioxidant activity according to the IC50 value. It seems that the anti-human esophageal cancer effect of recent nanoparticles is due to their antioxidant effects.

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出版当年[2021]版：

大类 | 4 区材料科学

小类 | 4 区化学综合 4 区纳米科技 4 区材料科学：综合 4 区物理：应用

最新[2025]版：

大类 | 4 区材料科学

小类 | 4 区化学：综合 4 区材料科学：综合 4 区纳米科技 4 区物理：应用

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出版当年[2020]版：

Q2 CHEMISTRY, MULTIDISCIPLINARY Q2 PHYSICS, APPLIED Q3 NANOSCIENCE & NANOTECHNOLOGY Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

最新[2023]版：

Q2 CHEMISTRY, MULTIDISCIPLINARY Q2 PHYSICS, APPLIED Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Q3 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 2.6 最新[2023版] 2.6 最新五年平均 3.075 出版当年[2020版] 3.269 出版当年五年平均 2.169 出版前一年[2019版] 2.024 出版后一年[2021版]

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第一作者单位： [1]Shanxi Canc Hosp, Dept Thorac Surg, Taiyuan, Peoples R China

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