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Deletion of MBD2 inhibits proliferation of chronic myeloid leukaemia blast phase cells

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收录情况： ◇ SCIE

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单位： [1]Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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关键词： methyl-CpG-binding domain protein 2 DNA methylation chronic myeloid leukaemia blast crisis therapeutic target SHP1 JAK2/STAT3 pathway

摘要：

Aberrant methylation of tumour suppressor genes is associated with the progression to a blast crisis in chronic myeloid leukaemia (CIVIL). Methyl-CpG-binding domain protein 2 (MBD2) has been studied as a "reader" of DNA methylation in many cancers, but its role in CIVIL is unclear. We constructed cell models of a homozygous deletion mutation of MBD2 using gene-editing technology in K562 cells and BV173 cells. Here, we demonstrated that the deletion of MBD2 inhibited cell proliferation capacity in vitro. MBD2 deletion also significantly inhibited K562 cell proliferation in a xenograft tumour model in vivo. Additionally, the JAK2/STAT3 signalling pathway, which is abnormally active in CIVIL, was inhibited by MBD2 deletion, and MBD2 deletion could up-regulate the expression of SHP1. In conclusion, our findings suggest that MBD2 is a candidate therapeutic strategy for the CIVIL blast phase.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2025]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

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出版当年[2016]版：

Q2 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 4.4 最新[2023版] 4.4 最新五年平均 3.294 出版当年[2016版] 3.38 出版当年五年平均 2.921 出版前一年[2015版] 3.373 出版后一年[2017版]

第一作者：

第一作者单位： [1]Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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通讯机构： [1]Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China [*1]Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road 1095#, Wuhan, Hubei, China, 430030.

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