Recent advances in the pathophysiologic understanding of coronavirus disease 2019 (COVID-19) suggests that cytokine release syndrome (CRS) has an association with the severity of disease, which is characterized by increased tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-2, IL-7, and IL-10. Hence, managing CRS has been recommended for rescuing severe COVID-19 patients. TNF-alpha, one of the pro-inflammatory cytokines commonly upregulated in acute lung injury, triggers CRS and facilitates SARS-CoV-2 interaction with angiotensin-converting enzyme 2 (ACE2). TNF-alpha inhibitors, therefore, may serve as an effective therapeutic strategy for attenuating disease progression in severe SARS-CoV-2 infection. Below, we review the possibilities and challenges of targeting the TNF-alpha pathway in COVID-19 treatment.
基金：
National Natural Science Foundation of China [82000729, 81873529]; Shanxi Province 136 Revitalization Medical Project Construction Fund
语种：
外文
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中科院(CAS)分区：
出版当年[2021]版：
大类|3 区医学
小类|3 区公共卫生、环境卫生与职业卫生
最新[2025]版：
大类|3 区医学
小类|3 区公共卫生、环境卫生与职业卫生
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出版当年[2020]版：
Q1PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTHQ2PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者单位：[1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Vasc Surg, Wuhan, Peoples R China[2]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Clin Ctr Human Gene Res, Wuhan, Peoples R China
通讯作者：
通讯机构：[4]Shanxi Med Univ, Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Shanxi Bethune Hosp,Dept Panc, Taiyuan, Peoples R China[5]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Canc Ctr, Wuhan, Peoples R China
推荐引用方式(GB/T 7714)：
Guo Yi,Hu Ke,Li Yuxuan,et al.Targeting TNF-α for COVID-19: Recent Advanced and Controversies[J].FRONTIERS IN PUBLIC HEALTH.2022,10:doi:10.3389/fpubh.2022.833967.
APA：
Guo, Yi,Hu, Ke,Li, Yuxuan,Lu, Chanjun,Ling, Ken...&Ye, Dawei.(2022).Targeting TNF-α for COVID-19: Recent Advanced and Controversies.FRONTIERS IN PUBLIC HEALTH,10,
MLA：
Guo, Yi,et al."Targeting TNF-α for COVID-19: Recent Advanced and Controversies".FRONTIERS IN PUBLIC HEALTH 10.(2022)
