Clinical and Pathological Implications of Increases in Tonsillar CD19+CD5+ B Cells, CD208+ Dendritic Cells, and IgA1-positive Cells of Immunoglobulin A Nephropathy
Objective Several studies indicated that tonsillectomy can improve the prognosis of patients with immunoglobulin A nephropathy (IgAN). However, the relationship between tonsillar immunity and IgAN is still unclear. Methods A total of 14 IgAN patients were recruited in the current study from May 2015 to April 2016 in Tongji Hospital. B cells, dendritic cells (DCs), and IgA1 positive cells in human tonsils were detected using immunofluorescence and immunohistochemistry. Correlations between these cells and clinicopathologic features were evaluated. Results CD19(+)CD5(+) B cells were predominantly located in germinal centers and mantle zones of lymphoid follicles, the CD208+ DCs were distributed in the interfollicular and subepithelial area, and IgA1-positive cells were predominantly detected in mantle zones of lymphoid follicles and subepithelial tissues. The numbers of CD19(+)CD5(+) B cells, CD208(+) DCs, and IgA1-positive cells in tonsillar tissues from IgAN patients were significantly higher than those in the normal controls (P<0.01, respectively). CD19(+)CD5(+) B cells, CD208(+) DCs, and IgA1-positive cells in tonsillar tissues were significantly associated with 24-h proteinuria levels and tubular atrophy/interstitial fibrosis of IgAN. Conclusion CD19(+)CD5(+) B cells, CD208(+) DCs, and IgA1-positive cells in tonsillar tissues might be involved in the pathogenesis of IgAN.
基金：
National Natural Science Foundation of China [82000658, 81770686, 81970591]; Huazhong University of Science and Technology research funds for self-dependent innovation [2017KFYXJJ101]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Nephrol,Dept Internal Med, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Cai Yang,Chen Mei-xue,Deng Yuan-jun,et al.Clinical and Pathological Implications of Increases in Tonsillar CD19+CD5+ B Cells, CD208+ Dendritic Cells, and IgA1-positive Cells of Immunoglobulin A Nephropathy[J].CURRENT MEDICAL SCIENCE.2022,42(1):93-99.doi:10.1007/s11596-022-2532-5.
APA：
Cai, Yang,Chen, Mei-xue,Deng, Yuan-jun,Liu, Le-le,Lin, Xue-ping...&Han, Min.(2022).Clinical and Pathological Implications of Increases in Tonsillar CD19+CD5+ B Cells, CD208+ Dendritic Cells, and IgA1-positive Cells of Immunoglobulin A Nephropathy.CURRENT MEDICAL SCIENCE,42,(1)
MLA：
Cai, Yang,et al."Clinical and Pathological Implications of Increases in Tonsillar CD19+CD5+ B Cells, CD208+ Dendritic Cells, and IgA1-positive Cells of Immunoglobulin A Nephropathy".CURRENT MEDICAL SCIENCE 42..1(2022):93-99
