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Hypertension Defined by 2017 ACC/AHA Guideline, Ideal Cardiovascular Health Metrics, and Risk of Cardiovascular Disease: A Nationwide Prospective Cohort Study.

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单位: [1]Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. [2]Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. [3]Qilu Hospital of Shandong University, Jinan, China. [4]Jiangxi People's Hospital, Nanchang, China. [5]The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [6]Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. [7]The Affiliated Hospital of Southwest Medical University, Luzhou, China. [8]Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [9]Affiliated Hospital of Guiyang Medical College, Guiyang, China. [10]Zhejiang Provincial Center for Disease Control and Prevention, China. [11]The First Hospital of Lanzhou University, Lanzhou, China. [12]Xinhua Hospital Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China. [13]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [14]The First Affiliated Hospital of Guangxi Medical University, Nanning, China. [15]Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China. [16]Dalian Municipal Central Hospital, Dalian, China. [17]The First Hospital of Jilin University, Changchun, China. [18]The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [19]Central Hospital of Shanghai Jiading District, Shanghai, China. [20]Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China. [21]The First Affiliated Hospital of Anhui Medical University, Hefei, China. [22]Karamay Municipal People's Hospital, Xinjiang, China. [23]The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [24]The Second Affiliated Hospital of Harbin Medical University, Harbin, China. [25]Chinese People's Liberation Army General Hospital, Beijing, China. [26]Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.
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关键词: Blood pressure Hypertension Cardiovascular health metrics Cardiovascular disease Cardiovascular prevention

摘要:
The updated definition of hypertension by the American College of Cardiology (ACC) and the American Heart Association (AHA) is an important paradigm shift and has lead to extensive discussion. We aimed to examine the association between the updated blood pressure (BP) categories and the risk of cardiovascular diseases (CVDs) with potential modifications from other cardiovascular health metrics (CVHMs).This prospective study included 91,204 participants ≥40 years recruited from 20 community sites across mainland China. Participants were followed up during 2010-2016 for CVD events including nonfatal myocardial infarction, stroke, heart failure, and cardiovascular death. BP categories were defined according to the 2017 ACC/AHA guideline and CVHMs included smoking, physical activity, diet, body-mass index, total cholesterol, and fasting glucose.Overall, 1,985 major CVD events occurred during a mean follow-up of 3.7 years. Having more ideal CVHMs significantly reduced the risk of CVD events in both stage 1 and stage 2 hypertension. Compared with participants without hypertension, participants having ≥4 ideal CVHMs were no longer associated with an increased CVD risk in stage 1 hypertension (HR=1·04; 95% CI=0·83-1·31), but less so in stage 2 hypertension (HR=1·90, 95% CI=1·70-2·13). Such pattern of association was more evident in participants aged <60 years (P for interaction <0·05).Stage 1 hypertension defined by the ACC/AHA identifies individuals at increased CVD risk, which can be attenuated by achieving more preferable cardiovascular health, especially in adults aged <60 years.© 2021 Published by Elsevier Ltd.

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大类 | 1 区 医学
小类 | 1 区 卫生保健与服务 1 区 公共卫生、环境卫生与职业卫生
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Q1 HEALTH CARE SCIENCES & SERVICES Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

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第一作者单位: [1]Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. [2]Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
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通讯机构: [1]Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. [2]Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. [*1]Shanghai National Clinical Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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