单位:[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Integrated Tradit Chinese & Western Med,Wuhan 430030,Peoples R China中医科中西医结合科华中科技大学同济医学院附属同济医院[2]Huazhong Univ Sci & Technol,Tongji Hosp,Inst Integrated Tradit Chinese & Western Med,Tongji Med Coll,Wuhan 430030,Peoples R China中西医结合研究所中西医结合科华中科技大学同济医学院附属同济医院
Background. Electroacupuncture (EA) may have a role in the treatment of diarrhea symptoms. However, the efficacy and safety of EA with different current intensities in improving gastrointestinal function, psychology, and quality of life (QOL) of functional diarrhea (FD) remain unknown. Objective. To investigate the efficacy and safety of EA with different current intensities in improving gastrointestinal function, psychology, and QOL for FD patients. Methods. 73 FD patients were randomly divided into three groups: low current intensity group (LI) of EA, high current intensity group (HI) of EA, and loperamide control group (LC). Four weeks of treatment were provided in the three groups. The primary outcome was the proportion of normal defecation. Additional outcomes included the change from baseline for the weekly spontaneous bowel movements (SBMs) and the change from baseline for the mean Bristol Stool Form Scale (BSFS). QOL was assessed by the 36-item short-form health survey (SF-36). Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were used to assess the psychology state. Results. Low current intensity of EA significantly improved the proportion of normal defecation during treatment and follow-up period (P < 0.01). EA significantly improves the mean BSFS scores and weekly SBMs, and this efficacy is equivalent to loperamide (P < 0.05). The SF-36 scores of general health in LI and HI groups and vitality and mental health in LI group were significantly increased compared to baseline (P < 0.05). Low current intensity of EA can significantly improve SAS and SDS scores (P < 0.05). Conclusions. EA significantly improved stool consistency and weekly SBMs in FD patients. Compared with loperamide, low current intensity of EA may have a better sustainable effect in restoring normal defecation in patients with FD, and it can also effectively improve QOL, anxiety, and depression. However, larger sample sizes are needed to determine safety and efficacy.
基金:
National Basic Research Program [2011CB505203]; National Natural Science Foundation of China [81603652, 81874388]
第一作者单位:[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Integrated Tradit Chinese & Western Med,Wuhan 430030,Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
Xu Xiaohu,Zhang Mingmin,Wu Xiao,et al.The Effect of Electroacupuncture Treatment with Different Intensities for Functional Diarrhea: A Randomized Controlled Trial[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2022,2022:doi:10.1155/2022/2564979.
APA:
Xu, Xiaohu,Zhang, Mingmin,Wu, Xiao,Zheng, Cuihong&Huang, Guangying.(2022).The Effect of Electroacupuncture Treatment with Different Intensities for Functional Diarrhea: A Randomized Controlled Trial.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2022,
MLA:
Xu, Xiaohu,et al."The Effect of Electroacupuncture Treatment with Different Intensities for Functional Diarrhea: A Randomized Controlled Trial".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2022.(2022)