Previous studies have shown that the high mortality caused by viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus primarily results from complications of a cytokine storm. Therefore, it is critical to identify the key factors participating in the cytokine storm. Here we demonstrate that interferon-induced protein 35 (IFP35) plays an important role in the cytokine storm induced by SARS-CoV-2 and influenza virus infection. We find that the levels of serum IFP35 in individuals with SARS-CoV-2 correlates with severity of the syndrome. Using mouse model and cell assays, we show that IFP35 is released by lung epithelial cells and macrophages after SARS-CoV-2 or influenza virus infection. In addition, we show that administration of neutralizing antibodies against IFP35 considerably reduces lung injury and, thus, the mortality rate of mice exposed to viral infection. Our findings suggest that IFP35 serves as a biomarker and as a therapeutic target in virus-induced syndromes.
基金：
National Natural Science Foundation of China [31870739, 82071346]; "Pearl River Talent Plan'' Innovation and Entrepreneurship Team Project of Guangdong Province [2019ZT08Y464]; Natural Science Foundation ofGuangdong Province, China [2020B1515020035]; Key Fundamental Research Projects of Shenzhen Science and Technology Plan [JCYJ20200109142418595]; Guangdong Specific Project for the Control of Novel Coronavirus [2020A111128023]
第一作者单位：[1]Sun Yat Sen Univ, Sch Med, Shenzhen 518107, Peoples R China
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Sch Med, Shenzhen 518107, Peoples R China[3]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Wuhan 430030, Hubei, Peoples R China[4]Hubei Key Lab Hepatopancreato Biliary Dis, Wuhan 430030, Hubei, Peoples R China[15]Sun Yat Sen Univ, Dept Colorectal Surg, Affiliated Hosp 6, Guangdong Inst Gastroenterol,Guangdong Prov Key L, Guangzhou 510655, Guangdong, Peoples R China[18]Chinese Acad Med Sci, Minist Educ, Key Lab Organ Transplantat, NHC Key Lab Organ Transplantat Key, Wuhan 430030, Hubei, Peoples R China
推荐引用方式(GB/T 7714)：
Yu Yang,Xu Na,Cheng Qi,et al.IFP35 as a promising biomarker and therapeutic target for the syndromes induced by SARS-CoV-2 or influenza virus[J].CELL REPORTS.2021,37(12):doi:10.1016/j.celrep.2021.110126.
APA：
Yu, Yang,Xu, Na,Cheng, Qi,Deng, Fei,Liu, Meiqin...&Liang, Huanhuan.(2021).IFP35 as a promising biomarker and therapeutic target for the syndromes induced by SARS-CoV-2 or influenza virus.CELL REPORTS,37,(12)
MLA：
Yu, Yang,et al."IFP35 as a promising biomarker and therapeutic target for the syndromes induced by SARS-CoV-2 or influenza virus".CELL REPORTS 37..12(2021)
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