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Design of a Metallacycle-Based Supramolecular Photosensitizer for In Vivo Image-Guided Photodynamic Inactivation of Bacteria.

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单位： [1]Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China [2]Department of Chemistry, University of Utah, 315 South 1400 East, Room 2020, Salt Lake City, Utah 84112, United States. [3]Department of Chemistry, University of Utah, 315 South 1400 East, Room 2020, Salt Lake City, Utah 84112, United States. [4]Guangxi Key laboratory of High-Incidence-Tumor Prevention & Treatment, Guangxi Medical University, Nanning 530021, China. [5]State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China.

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Bacterial infection is one of the greatest threats to public health. In vivo real-time monitoring and effective treatment of infected sites through non-invasive techniques, remain a challenge. Herein, we designed a Pt(II) metallacycle-based supramolecular photosensitizer through the host-guest interaction between a pillar[5]arene-modified metallacycle and 1-butyl-4-[4-(diphenylamino)styryl]pyridinium. Benefit from this design, such supramolecular photosensitizer, with aggregation-induced emission properties, demonstrated improved fluorescence performance and efficient photodynamic inactivation (PDI) of bacteria. In vivo studies revealed that it displayed precise fluorescence tracking of S. aureus -infected sites, and in situ performed image-guided efficient PDI of S. aureus without noticeable side effects. These results demonstrated that metallacycle combined with host-guest chemistry could provide a paradigm for the development of powerful photosensitizers for biomedicine.© 2021 Wiley-VCH GmbH.

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大类 | 1 区

化学

小类 | 1 区化学综合

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大类 | 1 区

化学

小类 | 1 区化学：综合

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出版当年[2020]版：

Q1 CHEMISTRY, MULTIDISCIPLINARY

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Q1 CHEMISTRY, MULTIDISCIPLINARY

影响因子： 16.1 最新[2023版] 16.2 最新五年平均 15.336 出版当年[2020版] 14.205 出版当年五年平均 12.959 出版前一年[2019版] 16.823 出版后一年[2021版]

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第一作者单位： [1]Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China

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