The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine.
基金：
Zhenan Technology City Research Fund; Ministry of Health Research Fund for Medical Sciences [WKJ-ZJ-1910]; Wenzhou Medical University [89218012]; Wenzhou Institute, University of Chinese Academy of Sciences [WIBEZD2017006-05]; Zhejiang Provincial [WKJ-ZJ-1910]
第一作者单位：[1]Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, Sch Biomed Engn, Wenzhou 325035, Peoples R China
通讯作者：
通讯机构：[1]Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, Sch Biomed Engn, Wenzhou 325035, Peoples R China[5]Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Peoples R China[7]Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Renal Div, Boston, MA 02115 USA[8]Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Boston, MA 02115 USA[9]Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA[10]Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA[11]Sungkyunkwan Univ, Inst Quantum Biophys, Dept Biophys, Suwon 16419, Gyeonggi Do, South Korea
推荐引用方式(GB/T 7714)：
Zhu Qingfu,Cheng Liming,Deng Chunyu,et al.The genetic source tracking of human urinary exosomes[J].PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.2021,118(43):doi:10.1073/pnas.2108876118j1of3.
APA：
Zhu, Qingfu,Cheng, Liming,Deng, Chunyu,Huang, Liu,Li, Jiaoyuan...&Liu, Fei.(2021).The genetic source tracking of human urinary exosomes.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,118,(43)
MLA：
Zhu, Qingfu,et al."The genetic source tracking of human urinary exosomes".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118..43(2021)
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