Intracerebral hemorrhage (ICH) is a devastating disease with high mortality and morbidity. Soluble epoxide hydrolase (sEH) is the key enzyme in the epoxyeicosatrienoic acids (EETs) signaling. sEH inhibition has been demonstrated to have neuroprotective effects against multiple brain injuries. However, its role in the secondary injuries after ICH has not been fully elucidated. Here we tested the hypothesis that 1-Trifluoromethoxyphenyl-3(1-propionylpiperidin-4-yl)urea (TPPU), a potent and highly selective sEH inhibitor, suppresses inflammation and the secondary injuries after ICH. Adult male C57BL/6 mice were subjected to a collagenase-induced ICH model. TPPU alleviated blood-brain barrier damage, inhibited inflammatory response, increased M2 polarization of microglial cells, reduced the infiltration of peripheral neutrophils. In addition, TPPU attenuated neuronal injury and promoted functional recovery. The results suggest that sEH may represent a potential therapeutic target for the treatment of ICH.
基金：
National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81974180, 82001272, 81571113]; Young excellent medical scholarship of Hubei Province [2020 LJRC011]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Neurol,1095 Jiefang Ave,Wuhan 430030,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Tian Yeye,Yuan Xiao,Wang Yao,et al.Soluble epoxide hydrolase inhibitor attenuates BBB disruption and neuroinflammation after intracerebral hemorrhage in mice[J].NEUROCHEMISTRY INTERNATIONAL.2021,150:doi:10.1016/j.neuint.2021.105197.
APA：
Tian,Yeye,Yuan,Xiao,Wang,Yao,Wu,Qiao,Fang,Yongkang...&Xie,Minjie.(2021).Soluble epoxide hydrolase inhibitor attenuates BBB disruption and neuroinflammation after intracerebral hemorrhage in mice.NEUROCHEMISTRY INTERNATIONAL,150,
MLA：
Tian,Yeye,et al."Soluble epoxide hydrolase inhibitor attenuates BBB disruption and neuroinflammation after intracerebral hemorrhage in mice".NEUROCHEMISTRY INTERNATIONAL 150.(2021)
