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Successful low-dose chemotherapy for refractory Epstein-Barr virus-related post-transplant lymphoproliferative disorder following hematopoietic stem cell transplantation in a child with Wiskott-Aldrich syndrome

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单位: [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Paediat, Wuhan, Peoples R China [2]Shanghai Jiao Tong Univ, Key Lab Paediat Haematol & Oncol, Shanghai Childrens Med Ctr, Minist Hlth,Dept Haematol & Oncol,Sch Med, Shanghai, Peoples R China [3]Huazhong Univ Sci & Technol, Wuhan Maternal & Child Healthcare Hosp, Wuhan Childrens Hosp, Dept Gynaecol,Tongji Med Coll, 100 Hong Kong Rd, Wuhan 433016, Peoples R China
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关键词: Epstein-Barr virus hematopoietic stem cell transplantation low-dose chemotherapy pediatric post-transplant lymphoproliferative disorder rituximab Wiskott-Aldrich syndrome

摘要:
We report the first case of a 12-year-old boy with Wiskott-Aldrich syndrome who developed CD20-weakly expressed and CD30-highly expressed Epstein-Barr virus-related post-transplant lymphoproliferative disorder refractory to rituximab treatment. The patient was effectively and safely treated with personalized low-dose chemotherapy and subsequently remained in complete remission for 1 year.

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大类 | 4 区 医学
小类 | 4 区 医学:内科
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Q3 MEDICINE, GENERAL & INTERNAL

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第一作者单位: [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Paediat, Wuhan, Peoples R China
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