单位：[1]Departments of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China[2]Department of Breast Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China华中科技大学同济医学院附属同济医院外科学系甲状腺乳腺外科
Abstract Toll-like receptors (TLRs) are probably the most important class of pattern-recognition receptors. Members of the
TLR family play key roles in the both innate and adaptive immune responses. Recognition of pathogen-associated molecular
patterns (PAMPs) by TLRs, either alone or in heterodimerization with other TLR or non-TLR receptors, induces the production
of signals that are responsible for the activation of genes important for an effective host defense, especially those of proinflammatory
cytokines. Thus, TLRs are involved in the development of many pathological conditions including infectious diseases,
tissue damage, and cancer especially. In this review, the contribution of TLRs to tumorgenesis is evaluated. We hope to provide
new insight into the progression of cancer and more importantly into the potential for TLRs as targets of therapeutics.
语种：
外文
第一作者：
第一作者单位：[1]Departments of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
通讯作者：
推荐引用方式(GB/T 7714)：
Lei He,Lin Zhang,Zhaofeng Li,et al.The roles of toll-like receptors in carcinogenesis and cancer immunotherapy[J].CHINESE-GERMAN JOURNAL OF CLINICAL ONCOLOGY.2010,doi:10.1007/s10330-010-0008-8.
APA：
Lei He,Lin Zhang,Zhaofeng Li&Quan Zhang.(2010).The roles of toll-like receptors in carcinogenesis and cancer immunotherapy.CHINESE-GERMAN JOURNAL OF CLINICAL ONCOLOGY,,
MLA：
Lei He,et al."The roles of toll-like receptors in carcinogenesis and cancer immunotherapy".CHINESE-GERMAN JOURNAL OF CLINICAL ONCOLOGY .(2010)
