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Etiological, epidemiological, and clinical features of acute diarrhea in China

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单位: [1]Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention,Beijing, China [2]Anhui Medical University, Hefei, China [3]State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology andEpidemiology, Beijing, China [4]National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention,Beijing, China [5]Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China [6]Sun Yat-sen University,Guangzhou, China [7]Yunnan Center for Disease Control and Prevention, Kunming, China [8]Shanghai Public Health Clinical Center, Shanghai, China [9]Zhejiang University, Hangzhou, China [10]Liaoning Provincial Center for Disease Control and Prevention, Shenyang, China [11]Gansu Provincial Center forDisease Control and Prevention, Lanzhou, China [12]Wuhan University, Wuhan, China [13]National Institute for Viral Disease Control and Prevention, ChineseCenter for Disease Control and Prevention, Beijing, China [14]WorldPop, School of Geography and Environmental Science, University of Southampton,Southampton, UK [15]Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai, China [16]FudanUniversity, Shanghai, China [17]The Institute for Disease Prevention and Control of PLA, Beijing, China [18]Department of Health Metrics Sciences, School ofMedicine, University of Washington, Seattle, WA, USA [19]Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA [20]Chinese Centre for Disease Control and Prevention, Beijing, China
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National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features of the 152,792 eligible patients enrolled in this analysis. Rotavirus A and norovirus are the two leading viral pathogens detected in the patients, followed by adenovirus and astrovirus. Diarrheagenic Escherichia coli and nontyphoidal Salmonella are the two leading bacterial pathogens, followed by Shigella and Vibrio parahaemolyticus. Patients aged <5 years had higher overall positive rate of viral pathogens, while bacterial pathogens were more common in patients aged 18‒45 years. A joinpoint analysis revealed the age-specific positivity rate and how this varied for individual pathogens. Our findings fill crucial gaps of how the distributions of enteropathogens change across China in patients with diarrhea. This allows enhanced identification of the predominant diarrheal pathogen candidates for diagnosis in clinical practice and more targeted application of prevention and control measures. © 2021, The Author(s).

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出版当年[2020]版:
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2025]版:
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
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第一作者单位: [1]Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention,Beijing, China
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通讯机构: [2]Anhui Medical University, Hefei, China [3]State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology andEpidemiology, Beijing, China [5]Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China
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