单位：[1]The Center for Biomedical Research,NHC Key Laboratory of Respiratory Diseases,Department of Respiratory and Critical Care Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China华中科技大学同济医学院附属同济医院生物医学研究中心内科学系呼吸与危重症医学科科研平台生物医学中心[2]Department of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China
Sepsis refers to the systemic inflammatory response syndrome caused by infection. It is a major clinical problem and cause of death for patients in intensive care units worldwide. The Fat mass and obesity-related protein (FTO) is the primary N (6)-methyladenosine demethylase. However, the role of FTO in the pathogenesis of inflammatory diseases remains unclear. We herein show that nanoparticle-mediated Fto-siRNA delivery or FTO inhibitor entacapone administration dramatically inhibited macrophage activation, reduced the tissue damage and improved survival in a mouse model of LPS-induced endotoxic shock. Importantly, ablation of FTO could inhibit NLRP3 inflammasome through FoxO1/NF-kappa B signaling in macrophages. In conclusion, FTO is involved in inflammatory response of LPS-induced septic shock and inhibition of FTO is promising for the treatment of septic shock.
基金：
Ministry of Science and Technology [2016YFC1305002, 2017YFC1309603]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81530024, 91749207, 81920108009, 81770823, 81670729, 81873656]; NHC Drug Discovery Program [2017ZX09304022-07]; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College, Huazhong University of Science and Technology; Innovative Funding for Translational Research from Tongji Hospital
第一作者单位：[1]The Center for Biomedical Research,NHC Key Laboratory of Respiratory Diseases,Department of Respiratory and Critical Care Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
通讯作者：
推荐引用方式(GB/T 7714)：
luo jiahui,wang faxi,sun fei,et al.Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome[J].FRONTIERS IN IMMUNOLOGY.2021,12:doi:10.3389/fimmu.2021.663295.
APA：
luo,jiahui,wang,faxi,sun,fei,yue,tiantian,zhou,qing...&li,jinxiu.(2021).Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome.FRONTIERS IN IMMUNOLOGY,12,
MLA：
luo,jiahui,et al."Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome".FRONTIERS IN IMMUNOLOGY 12.(2021)
医学