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Overexpression of KDM4D promotes acute myeloid leukemia cell development by activating MCL-1

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收录情况： ◇ SCIE ◇ 预警期刊

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单位： [1]Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Hepatopancreatobiliary Surg, Gusao Tree Rd 16 Jianghan Dist, Wuhan 430000, Hubei, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Thorac Surg, Wuhan 430040, Peoples R China [3]Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Tongji Med Coll, 100 Xiang Gang Rd, Wuhan 430000, Hubei, Peoples R China

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关键词： KDM4D MCL-1 proliferation cell cycle AML apoptosis

摘要：

Acute myeloid leukemia (AML) is regarded as a fatal cancer in the world. The overall survival in adult patients with AML is still poor. As lysine demethylases, the KDM4 family is found highly expressed in many kinds of tumors. In this study, we demonstrate that KDM4D is overexpressed in AML and knockdown of KDM4D not only inhibits the proliferation of AML cells, but also induces cell cycle arrest and apoptosis. Furthermore, our research shows that KDM4D can regulate the expression of MCL-1 by demethylating H3K9me3 at the promoter region in AML cells. Besides, we find that high expression of KDM4D is correlated with poor overall survival in AML patients. Taken together, our study demonstrated that KDM4D can promote MCL-1 expression in AML and may serve as a novel target for the treatment of AML.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区医学：研究与实验 3 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

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出版当年[2019]版：

Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 ONCOLOGY

最新[2023]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q4 ONCOLOGY

影响因子： 1.7 最新[2023版] 2.3 最新五年平均 3.375 出版当年[2019版] 3.404 出版当年五年平均 3.266 出版前一年[2018版] 4.06 出版后一年[2020版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Hepatopancreatobiliary Surg, Gusao Tree Rd 16 Jianghan Dist, Wuhan 430000, Hubei, Peoples R China

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