单位：[1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,People’s Republic of China华中科技大学同济医学院附属同济医院妇产科教研室妇产科学系[2]Cancer Biology Research Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,People’s Republic of China华中科技大学同济医学院附属同济医院肿瘤生物医学中心[3]Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,People’s Republic of China华中科技大学同济医学院附属同济医院外科学系泌尿外科
High-grade serous ovarian cancer (HGSOC) has abundant expression of hormone receptors, including androgen receptor (AR), estrogen receptor alpha (ER), and progesterone receptor (PR). The effects of hormone receptors on prognosis of HGSOC were first evaluated in online databases. Their prognostic values were then explored and validated in our inhouse TJ-cohort (92 HGSOC patients) and in a validation cohort (33 HGSOC patients), wherein hormone receptors were detected immunohistochemically. High expression of hormone receptors denoted longer progression-free survival (PFS), overall survival (OS), and platinum-free interval (PFI). Platinum-sensitive patients had higher expression of hormone receptors than their counterparts. Correlation analysis revealed significant positive correlations between hormone receptors expression and survival. AR, ER, and PR had predictive and prognostic values, alone and in combination. By receiver operating characteristic curve (ROC) analysis, co-expression of AR, ER, and PR had an improved predictive performance with an area under the curve (AUC) value of 0.945. Expression of hormone receptors predicts survival and platinum sensitivity of HGSOC. AR, ER, and PR might be feasible prognostic biomarkers for HGSOC by immunohistochemical analysis.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82072889, 81974405]
第一作者单位：[1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,People’s Republic of China[2]Cancer Biology Research Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,People’s Republic of China[2]Cancer Biology Research Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,People’s Republic of China
推荐引用方式(GB/T 7714)：
tan jiahong,song chunyan,wang daoqi,et al.Expression of hormone receptors predicts survival and platinum sensitivity of high-grade serous ovarian cancer[J].BIOSCIENCE REPORTS.2021,41(5):doi:10.1042/BSR20210478.
APA：
tan,jiahong,song,chunyan,wang,daoqi,hu,yigang,liu,dan...&gao,qinglei.(2021).Expression of hormone receptors predicts survival and platinum sensitivity of high-grade serous ovarian cancer.BIOSCIENCE REPORTS,41,(5)
MLA：
tan,jiahong,et al."Expression of hormone receptors predicts survival and platinum sensitivity of high-grade serous ovarian cancer".BIOSCIENCE REPORTS 41..5(2021)
